open access

Vol 2, No 3 (2013)
Review
Published online: 2013-05-21
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Advanced glycation end products. A new biomarker of diabetes and late complications of disease?

Bogna Wierusz-Wysocka, Aleksandra Araszkiewicz, Judyta Schlaffke
Diabetologia Kliniczna 2013;2(3):96-103.

open access

Vol 2, No 3 (2013)
Review
Published online: 2013-05-21

Abstract

Since DCCT study HbA1c plays the role of biomarker oflate diabetes complications. In the last years however ithas been suggested that HbA1c does not exactly refl ectstrue course of the disease. Therefore, intensive effortsare made to fi nd other, more precise tools for monitoringthe metabolic state of diabetic patients. Estimationsof advanced glycation end-products (AGEs) inserum or tissues seems to be one of the options. Newpossibility of non-invasive assessment of AGEs isprovided by the use of skin collagen fl uorescence. Inseveral studies in diabetic patients the positive correlationbetween skin autofl uorescence, HbA1c value andmicrovascular complications was reported. It seemsthat in the future this phenomenon could be used asa useful method for clinical monitoring of diabetescourse.

Abstract

Since DCCT study HbA1c plays the role of biomarker oflate diabetes complications. In the last years however ithas been suggested that HbA1c does not exactly refl ectstrue course of the disease. Therefore, intensive effortsare made to fi nd other, more precise tools for monitoringthe metabolic state of diabetic patients. Estimationsof advanced glycation end-products (AGEs) inserum or tissues seems to be one of the options. Newpossibility of non-invasive assessment of AGEs isprovided by the use of skin collagen fl uorescence. Inseveral studies in diabetic patients the positive correlationbetween skin autofl uorescence, HbA1c value andmicrovascular complications was reported. It seemsthat in the future this phenomenon could be used asa useful method for clinical monitoring of diabetescourse.
Get Citation

Keywords

diabetes, advanced glycation end products, biomarker, skin autofl uorescence

About this article
Title

Advanced glycation end products. A new biomarker of diabetes and late complications of disease?

Journal

Clinical Diabetology

Issue

Vol 2, No 3 (2013)

Pages

96-103

Published online

2013-05-21

Bibliographic record

Diabetologia Kliniczna 2013;2(3):96-103.

Keywords

diabetes
advanced glycation end products
biomarker
skin autofl uorescence

Authors

Bogna Wierusz-Wysocka
Aleksandra Araszkiewicz
Judyta Schlaffke

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