Vol 1, No 6 (2012)
Case report
Published online: 2013-03-11

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A patient with Laron syndrome and diabetes: case study

Paulina Marta Linkowska, Magdalena Radomska, Adrian Ireneusz Stefański, Hanna Jasiel-Wojculewicz
Diabetologia Kliniczna 2012;1(6):219-222.


Laron syndrome is a rare genetic disease, characterised
by dwarfi sm, typical facial features and central obesity.
In the basis of pathomechanism lies resistance of
growth hormone receptor which leads to insuffi ciency
of IGF 1 (IGF 1, insulin like growth factor 1). Within
the population of patients with Laron syndrome, it
has been observed that they are less likely to develop
malignant tumour and diabetes mellitus. It is probably
caused by IGF1 insuffi ciency. If some patients develop
diabetes mellitus, it is caused by insulin resistance
growing with age.
In this report a case of 20 year old female with Larone
syndrome and diabetes is presented. The patient
developed absolute insulin insuffi ciency. Patient was
admitted because of uncontrolled diabetes with glucose
levels ranging from 30 mg/dl (1.67 mmol/l) to about
1000 mg/dl (55.5 mmol/l). During the hospitalisation
the patient’s insulin therapy has been modifi ed. Due
to highly probable insulin resistance compound, it has
been decided to start the treatment with metformin,
aiming to gain better glucose control.

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