open access

Vol 1, No 3 (2012)
Review articles (submitted)
Published online: 2012-09-05
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Matrix metalloproteinases and their inhibitors. The role in the development of diabetic microangiopathy

Agnieszka Kłych, Agnieszka Kosowska
Diabetologia Kliniczna 2012;1(3):114-120.

open access

Vol 1, No 3 (2012)
Review articles (submitted)
Published online: 2012-09-05

Abstract

Microangiopathy is the chronic diabetic complication.
It is associated with disorders in small blood
vessels — diameter less than 100 μm. The most important
clinical changes occur in the retina (retinopathy),
kidneys (nephropathy), nervous system (neuropathy)
and in the heart (cardiomyopathy). These
changes are primarily connected with smooth muscle
cells proliferation, extracellular matrix expansion
and thickening of the intima. It is thought that their
development is due to disturbances in the matrix
metalloproteinases system. Consequently, the role
of these enzymes in the development of diabetic
complications has been the subject of intensive research.
This report summarizes the contribution of
metalloproteinases to diabetic microangiopathy.

Abstract

Microangiopathy is the chronic diabetic complication.
It is associated with disorders in small blood
vessels — diameter less than 100 μm. The most important
clinical changes occur in the retina (retinopathy),
kidneys (nephropathy), nervous system (neuropathy)
and in the heart (cardiomyopathy). These
changes are primarily connected with smooth muscle
cells proliferation, extracellular matrix expansion
and thickening of the intima. It is thought that their
development is due to disturbances in the matrix
metalloproteinases system. Consequently, the role
of these enzymes in the development of diabetic
complications has been the subject of intensive research.
This report summarizes the contribution of
metalloproteinases to diabetic microangiopathy.
Get Citation

Keywords

matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases, diabetic microangiopathy

About this article
Title

Matrix metalloproteinases and their inhibitors. The role in the development of diabetic microangiopathy

Journal

Clinical Diabetology

Issue

Vol 1, No 3 (2012)

Pages

114-120

Published online

2012-09-05

Bibliographic record

Diabetologia Kliniczna 2012;1(3):114-120.

Keywords

matrix metalloproteinases
tissue inhibitors of matrix metalloproteinases
diabetic microangiopathy

Authors

Agnieszka Kłych
Agnieszka Kosowska

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