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Matrix metalloproteinases and their inhibitors. The role in the development of diabetic microangiopathy
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Abstract
It is associated with disorders in small blood
vessels — diameter less than 100 μm. The most important
clinical changes occur in the retina (retinopathy),
kidneys (nephropathy), nervous system (neuropathy)
and in the heart (cardiomyopathy). These
changes are primarily connected with smooth muscle
cells proliferation, extracellular matrix expansion
and thickening of the intima. It is thought that their
development is due to disturbances in the matrix
metalloproteinases system. Consequently, the role
of these enzymes in the development of diabetic
complications has been the subject of intensive research.
This report summarizes the contribution of
metalloproteinases to diabetic microangiopathy.
Abstract
It is associated with disorders in small blood
vessels — diameter less than 100 μm. The most important
clinical changes occur in the retina (retinopathy),
kidneys (nephropathy), nervous system (neuropathy)
and in the heart (cardiomyopathy). These
changes are primarily connected with smooth muscle
cells proliferation, extracellular matrix expansion
and thickening of the intima. It is thought that their
development is due to disturbances in the matrix
metalloproteinases system. Consequently, the role
of these enzymes in the development of diabetic
complications has been the subject of intensive research.
This report summarizes the contribution of
metalloproteinases to diabetic microangiopathy.
Keywords
matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases, diabetic microangiopathy
About this articleTitle
Matrix metalloproteinases and their inhibitors. The role in the development of diabetic microangiopathy
Journal
Issue
Article type
Review article
Pages
114-120
Published online
2012-09-05
Page views
834
Article views/downloads
1287
Bibliographic record
Diabetologia Kliniczna 2012;1(3):114-120.
Keywords
matrix metalloproteinases
tissue inhibitors of matrix metalloproteinases
diabetic microangiopathy
Authors
Agnieszka Kłych
Agnieszka Kosowska