Vol 1, No 2 (2012)
Research paper
Published online: 2012-06-01

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Prevalence of hyperfiltration in type 2 diabetes patients

Konrad Walczak, Irmina Korzeniewska-Dyl, Anna Krysicka, Małgorzata Sodolska, Dariusz Moczulski
Diabetologia Kliniczna 2012;1(2):49-54.


Background. The role of hyperfiltration in thepathomechanism of diabetic kidney disease has notbeen well explained. The aim of this study was todetermine the prevalence of hyperfiltration in patientswith type 2 diabetes. The association betweenhyperfiltration and clinical parameters were analyzed.

Material and methods. 150 patients with type 2diabetes and eGFR > 60 ml/min/1.73 m2 wereexamined. Serum cystatin C concentration wasassessed in each patients and glomerular filtrationrate (eGFR) was estimated. Hyperfiltration was defineas eGFR > 134 ml/min/1.73 m2 in men and eGFR> 149 ml/min/1.73 m2 in women.

Results. Hyperfiltration was present in 20 (13.3%) of150 analyzed patients. Hyperfiltration was found in 9 women and 11 men. There was no difference between patient with and without hyperfiltrationaccording to concentration of potassium,triglycerides, total cholesterol and CRP. Also, urinaryalbumin excretion in both groups did not differ fromeach other. People with hyperfiltration had a shorterduration of diabetes from diagnosis and wereyounger. Patients with hyperfiltration had higherHbA1c and lower BMI than subjects withouthyperfiltration. Hyperfiltration was less frequent inpatients taking inhibitors of angiotensin convertingenzyme (ACEI) and angiotensin II receptor blockers(ARB).

Conclusions. Hyperfiltration is rare in patients withtype 2 diabetes. Poor glycemic control increases riskof hyperfiltration, but age and BMI dicrease the risk.Hyperfiltration is less frequently in patients takingACEI and ARB.

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