open access

Vol 1, No 1 (2012)
Research paper
Published online: 2012-04-11
Get Citation

Pancreatic cancer in type 2 diabetic patient treated with 3 oral agents including dipeptidil-peptidase-IV inhibitor

Mariusz Dąbrowski
Diabetologia Kliniczna 2012;1(1):12-16.

open access

Vol 1, No 1 (2012)
Original articles (submitted)
Published online: 2012-04-11

Abstract

Risk of pancreatic cancer is elevated in subjects withtype 2 diabetes. Recently also concerns regarding increasedrisk of pancreatitis and pancreatic cancer inpatients receiving incretin-based therapy has beenarisen. Early stages of the disease are usually asymptomatic.Hence, 80–85% of pancreatic cancer casesare diagnosed in an advanced stage. Painless jaundice,upper abdomen or back pain, malabsorption,cachexia, depression and thromboembolism are mostcommon clinical features of the pancreatic cancer.In this report a case of a 68 years old, slightly overweightedmale subject with a long standing type 2diabetes is described. Patient was treated with sulfonylurea,metformin and DPP-IV (dipeptidyl peptidase-IV) inhibitor, and good metabolic control of diabetes (HbA1c £ 7,0%) was maintained. During oneof the planned, consecutive visits, a significant, non-intentional 5 kg weight loss within the preceding4 months was noted. Patient was asymptomatic.However, after the diagnostic procedures, the diagnosisof pancreatic cancer was established.This case indicate the need for awareness and forthorough diagnostics of every unexpected, non-intentionalweight loss in diabetic patient. Even asymptomatic,it may be a sign of neoplastic process inthe abdomen cavity, with a special attention to pancreaticcarcinoma. (Diabet. Klin. 2012; 1, 1: 12–16)

Abstract

Risk of pancreatic cancer is elevated in subjects withtype 2 diabetes. Recently also concerns regarding increasedrisk of pancreatitis and pancreatic cancer inpatients receiving incretin-based therapy has beenarisen. Early stages of the disease are usually asymptomatic.Hence, 80–85% of pancreatic cancer casesare diagnosed in an advanced stage. Painless jaundice,upper abdomen or back pain, malabsorption,cachexia, depression and thromboembolism are mostcommon clinical features of the pancreatic cancer.In this report a case of a 68 years old, slightly overweightedmale subject with a long standing type 2diabetes is described. Patient was treated with sulfonylurea,metformin and DPP-IV (dipeptidyl peptidase-IV) inhibitor, and good metabolic control of diabetes (HbA1c £ 7,0%) was maintained. During oneof the planned, consecutive visits, a significant, non-intentional 5 kg weight loss within the preceding4 months was noted. Patient was asymptomatic.However, after the diagnostic procedures, the diagnosisof pancreatic cancer was established.This case indicate the need for awareness and forthorough diagnostics of every unexpected, non-intentionalweight loss in diabetic patient. Even asymptomatic,it may be a sign of neoplastic process inthe abdomen cavity, with a special attention to pancreaticcarcinoma. (Diabet. Klin. 2012; 1, 1: 12–16)

Get Citation

Keywords

pancreatic cancer; type 2 diabetes; incretin axis; glucagon-like peptide-1; DPP-IV inhibitors

About this article
Title

Pancreatic cancer in type 2 diabetic patient treated with 3 oral agents including dipeptidil-peptidase-IV inhibitor

Journal

Clinical Diabetology

Issue

Vol 1, No 1 (2012)

Article type

Research paper

Pages

12-16

Published online

2012-04-11

Bibliographic record

Diabetologia Kliniczna 2012;1(1):12-16.

Keywords

pancreatic cancer
type 2 diabetes
incretin axis
glucagon-like peptide-1
DPP-IV inhibitors

Authors

Mariusz Dąbrowski

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

 

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl