open access

Vol 12, No 1 (2011): Practical Diabetology
Review paper
Published online: 2011-04-28
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Is there a progress in treatment of dyslipidemia in diabetes? What are the results of ACCORD study?

Barbara Idzior-Waluś, Małgorzata Waluś-Miarka
Diabetologia Praktyczna 2011;12(1):1-5.

open access

Vol 12, No 1 (2011): Practical Diabetology
Review articles (submitted)
Published online: 2011-04-28

Abstract

In this article ACCORD Study results, concerning clinical efficacy in preventing cardiovascular disease and safety of combined statin and fibrate treatment in patients with type 2 diabetes in comparison to statin monotherapy are presented. Study included 5518 patients with type 2 diabetes, treated with simvastatin and fenofibrate in comparison to simvastatin and placebo. After 4.7 years of treatment no significant differences in primary end points (cardiac death, myocardial infarction and stroke) were observed between compared groups. However, favourable trend of combined therapy in comparison to statin monotherapy in the subgroup of patients with low HDL-cholesterol and high triglycerides — lipid profile typical for atherogenic dyslipidemia — 31% decrease of cardiovascular end-points was observed. The results of ACCORD Lipid Study suggest combined therapy according to patients’ lipid profile. (Diabet. Prakt. 2011; 12, 1: 1–5)

Abstract

In this article ACCORD Study results, concerning clinical efficacy in preventing cardiovascular disease and safety of combined statin and fibrate treatment in patients with type 2 diabetes in comparison to statin monotherapy are presented. Study included 5518 patients with type 2 diabetes, treated with simvastatin and fenofibrate in comparison to simvastatin and placebo. After 4.7 years of treatment no significant differences in primary end points (cardiac death, myocardial infarction and stroke) were observed between compared groups. However, favourable trend of combined therapy in comparison to statin monotherapy in the subgroup of patients with low HDL-cholesterol and high triglycerides — lipid profile typical for atherogenic dyslipidemia — 31% decrease of cardiovascular end-points was observed. The results of ACCORD Lipid Study suggest combined therapy according to patients’ lipid profile. (Diabet. Prakt. 2011; 12, 1: 1–5)
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Keywords

diabetic dyslipidemia; combined therapy; fibrates; statins

About this article
Title

Is there a progress in treatment of dyslipidemia in diabetes? What are the results of ACCORD study?

Journal

Clinical Diabetology

Issue

Vol 12, No 1 (2011): Practical Diabetology

Article type

Review paper

Pages

1-5

Published online

2011-04-28

Bibliographic record

Diabetologia Praktyczna 2011;12(1):1-5.

Keywords

diabetic dyslipidemia
combined therapy
fibrates
statins

Authors

Barbara Idzior-Waluś
Małgorzata Waluś-Miarka

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