open access

Vol 12, No 3 (2011): Practical Diabetology
Original articles (submitted)
Published online: 2011-10-10
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Cistatin C as an early marker for renal function loss in type 2 diabetic patients with concomitant albuminuria

Katarzyna Wasilewska, Iwona Jakubowska, Jolanta Czyżewska, Joanna Kamińska, Halina Kemona
Diabetologia Praktyczna 2011;12(3):103-112.

open access

Vol 12, No 3 (2011): Practical Diabetology
Original articles (submitted)
Published online: 2011-10-10

Abstract

BACKGROUND. Type 2 diabetes is the main cause of the end-stage renal insufficiency needed renal replacement therapy. Vascular damage turn leads to diabetic nephropathy leads and progress from onset of hyperglycemia. Albuminuria is first laboratory indicator confirm the damage of the renal glomerulus. Cystatin C is sensitive marker of a developing renal dysfunction. Aim of the research: what are the relations between concentration of cystatin C in blood and albuminuria and HbA1c in type 2 diabetes?
MATERIAL AND METODS. The research included 68 patients with type 2 diabetes and confirmed albuminuria. Based on the degree of metabolic control expressed by the percentage of HbA1c, the patients were divided into two groups: I group — 29 patients with type 2 diabetes with HbA1c ≥ 6.1% to £ 6.5%, with the average duration of diabetes of 5.3 years. II group — 39 patients with type 2 diabetes with HbA1c > 6.5% to £ 10.0%, with the average duration of diabetes of 7.2 years. K — the control group consisted of 21 patients with essential hypertension and albuminuria, not suffering from carbohydrates disorders. Concentration cystatin C in blood was assessed with the ELISA test, the percentage of HbA1c was measured immunoturbidimetric method. A Mann-Whitney test was used for the comparison between the values of the parameters in the research groups and the control group. Spearman’s rank correlation coefficient was used for measuring the relation between the axtent of albuminuria and the other parameters.
RESULTS. The average concentration of HbA1c in group II was 7.54% and was connected with significantly larger average glycaemia (p < 0.001) in comparison with group I with normal HbA1c concentration. The highest albumin excretion in urine and highest average concentration cystatin C in blood was in group II patients with type 2 diabetes with HbA1c > 6.5% to £ 10.0%. In group II patients with type 2 diabetes and abnormal metabolic control the average concentration of cystatin C was significantly higher than in the control group patients with essential hypertension. This difference however was not statistically significant. Nevertheless a positive correlation was found between the concentration of cystatin C in blood and the extent of albuminuria in research group I patients with type 2 diabetes with HbA1c < 6.5% (p = 0.005).
CONCLUSIONS. The positive correlation between the concentration of cystatin C and the extent of albuminuria, found in the research on patients with type 2 diabetes and normal percentage of HbA1c (p = 0.005) with shorts average duration of diabetes about of 5 years, confirms the sensitivity of this marker even at early stages of renal dysfunction.
(Diabet. Prakt. 2011; 12, 3: 103–112)

Abstract

BACKGROUND. Type 2 diabetes is the main cause of the end-stage renal insufficiency needed renal replacement therapy. Vascular damage turn leads to diabetic nephropathy leads and progress from onset of hyperglycemia. Albuminuria is first laboratory indicator confirm the damage of the renal glomerulus. Cystatin C is sensitive marker of a developing renal dysfunction. Aim of the research: what are the relations between concentration of cystatin C in blood and albuminuria and HbA1c in type 2 diabetes?
MATERIAL AND METODS. The research included 68 patients with type 2 diabetes and confirmed albuminuria. Based on the degree of metabolic control expressed by the percentage of HbA1c, the patients were divided into two groups: I group — 29 patients with type 2 diabetes with HbA1c ≥ 6.1% to £ 6.5%, with the average duration of diabetes of 5.3 years. II group — 39 patients with type 2 diabetes with HbA1c > 6.5% to £ 10.0%, with the average duration of diabetes of 7.2 years. K — the control group consisted of 21 patients with essential hypertension and albuminuria, not suffering from carbohydrates disorders. Concentration cystatin C in blood was assessed with the ELISA test, the percentage of HbA1c was measured immunoturbidimetric method. A Mann-Whitney test was used for the comparison between the values of the parameters in the research groups and the control group. Spearman’s rank correlation coefficient was used for measuring the relation between the axtent of albuminuria and the other parameters.
RESULTS. The average concentration of HbA1c in group II was 7.54% and was connected with significantly larger average glycaemia (p < 0.001) in comparison with group I with normal HbA1c concentration. The highest albumin excretion in urine and highest average concentration cystatin C in blood was in group II patients with type 2 diabetes with HbA1c > 6.5% to £ 10.0%. In group II patients with type 2 diabetes and abnormal metabolic control the average concentration of cystatin C was significantly higher than in the control group patients with essential hypertension. This difference however was not statistically significant. Nevertheless a positive correlation was found between the concentration of cystatin C in blood and the extent of albuminuria in research group I patients with type 2 diabetes with HbA1c < 6.5% (p = 0.005).
CONCLUSIONS. The positive correlation between the concentration of cystatin C and the extent of albuminuria, found in the research on patients with type 2 diabetes and normal percentage of HbA1c (p = 0.005) with shorts average duration of diabetes about of 5 years, confirms the sensitivity of this marker even at early stages of renal dysfunction.
(Diabet. Prakt. 2011; 12, 3: 103–112)
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Keywords

type 2 diabetes; hyperglycemia; albuminuria; diabetes nephropathy; cystatine C

About this article
Title

Cistatin C as an early marker for renal function loss in type 2 diabetic patients with concomitant albuminuria

Journal

Clinical Diabetology

Issue

Vol 12, No 3 (2011): Practical Diabetology

Pages

103-112

Published online

2011-10-10

Bibliographic record

Diabetologia Praktyczna 2011;12(3):103-112.

Keywords

type 2 diabetes
hyperglycemia
albuminuria
diabetes nephropathy
cystatine C

Authors

Katarzyna Wasilewska
Iwona Jakubowska
Jolanta Czyżewska
Joanna Kamińska
Halina Kemona

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