The role the sulphonylurea drugs in therapy of type 2 diabetes. Whether all derivates from this group equally affect on mortality from general causes and cardiovascular risk?

Abstract

Lowering the blood glucose level has a key importance in the prevention and the inhibition of progression of late diabetic complications (macroand microvascular). This purpose is being accomplished through the change of a lifestyle and the use of antidiabetic drugs. The sulphonylurea are one of important groups of drugs in this regard. At the present paper I presented: mechanism of action of the sulphonylurea drugs, preparats of the sulphonylurea drugs available on the Polish market and new findings about the differences of the sulphonylurea action on the risk of the death for general reasons and to the cardiovascular risk. I showed in presented findings, that out of all derivatives of the sulphonylurea only gliclazyd in the significant way influenced for lowering the risk of deaths for general reasons and for cardiovascular reasons. After describing examinations a suggestion arose, that from amongst derivatives of the sulphonylurea gliclazyd should be a medicine by choice.
(Diabet. Prakt. 2011; 12, 3: 79–89)