Vol 12, No 5 (2011): Practical Diabetology
Review article
Published online: 2011-12-29
Linagliptin — a novel dipeptidyl peptidase-IV inhibitor
Diabetologia Praktyczna 2011;12(5):161-169.
Abstract
The diabetes and its complications is one of the five
most frequent causes of deaths in the developed
countries. So far applied therapeutic proceedings of
type 2 diabetic subjects weren’t truly effective. To
the purpose of the improvement the results of the
treatment one should intensify current therapeutic
proceedings or/and enter new groups of drugs into
the treatment. One of new groups of drugs released
on the market in the last period are being associated
with much hope are gliptin — dipeptidyl peptidase-
IV inhibitors (DPP-IV). Linagliptin is a new DPP-IV
inhibitor. Authors demonstrated, that linagliptin
assures meaning statistically and essential clinically
effectiveness in all therapeutic outlines at present
applied, so like of the monotherapy, supply with
metformin, with metformin and sulphonylurea
as well as initial association with pioglitazon.
Improvement in the control of the blood glucose level
as a result of the treatment linagliptin HbA1c, FGP
and PPG values, meaning beneficial changes and the
improvement in parameters of functioning of beta
cells observed. Risk of side effects, particularly a risk of the appearance of the hypoglycemia is similar
like applying in placebo group. (Diabet. Prakt. 2011;
12, 5: 161–169)
Keywords: type 2 diabeteslinagliptinstructuremechanism of actionapplicationside effects