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Vol 19, No 1-2 (2017)
Review articles
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Ruscus aculeatus extract in the therapy of chronic venous disorders

Jerzy Chudek, Damian Ziaja
Chirurgia Polska 2017;19(1-2):13-17.

open access

Vol 19, No 1-2 (2017)
Review articles

Abstract

Treatment of chronic venous disorders combines conservative treatment, which includes compression therapy and use of pharmacotherapy, and surgical procedures. Venoactive drugs are recommended for all stages of chronic venous disorders.

One of the most commonly used venoactive drugs are extracts from butcher's broom (Ruscus aculeatus). They contain saponins sterols: ruscogenin and neoruscogenin that reduce vascular permeability, exhibit anti-inflammatory, vasoconstrictor, and anticoagulants actions, and inhibit the activity of elastase damaging the elastin fibers. Preparations containing Ruscus aculeatus extract used to reduce the severity of chronic pain, cramps, heaviness of the legs and paresthesias, as well as reduce the residual venous volume of the lower extremities (0.7 ml/100 ml), leading to a decrease in calf (by 7.3 mm) and ankle circumferences (by 11.7 mm) and the reduction of the lower limb edema in patients with chronic venous disorders. A comparable effect of preparations containing diosmin and butcher's broom extract, on the healing process of venous ulcers was recently showed in an observational study.

The efficacy of formulations containing extracts of Ruscus aculeatus in alleviating symptoms of chronic venous disorders has been confirmed in a randomized trial with the placebo

Abstract

Treatment of chronic venous disorders combines conservative treatment, which includes compression therapy and use of pharmacotherapy, and surgical procedures. Venoactive drugs are recommended for all stages of chronic venous disorders.

One of the most commonly used venoactive drugs are extracts from butcher's broom (Ruscus aculeatus). They contain saponins sterols: ruscogenin and neoruscogenin that reduce vascular permeability, exhibit anti-inflammatory, vasoconstrictor, and anticoagulants actions, and inhibit the activity of elastase damaging the elastin fibers. Preparations containing Ruscus aculeatus extract used to reduce the severity of chronic pain, cramps, heaviness of the legs and paresthesias, as well as reduce the residual venous volume of the lower extremities (0.7 ml/100 ml), leading to a decrease in calf (by 7.3 mm) and ankle circumferences (by 11.7 mm) and the reduction of the lower limb edema in patients with chronic venous disorders. A comparable effect of preparations containing diosmin and butcher's broom extract, on the healing process of venous ulcers was recently showed in an observational study.

The efficacy of formulations containing extracts of Ruscus aculeatus in alleviating symptoms of chronic venous disorders has been confirmed in a randomized trial with the placebo

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Keywords

Ruscus aculeatus extract, ruscogenin, neoruscogenin, chronic venous insufficiency, chronic venous disorders

About this article
Title

Ruscus aculeatus extract in the therapy of chronic venous disorders

Journal

Chirurgia Polska (Polish Surgery)

Issue

Vol 19, No 1-2 (2017)

Pages

13-17

Bibliographic record

Chirurgia Polska 2017;19(1-2):13-17.

Keywords

Ruscus aculeatus extract
ruscogenin
neoruscogenin
chronic venous insufficiency
chronic venous disorders

Authors

Jerzy Chudek
Damian Ziaja

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