open access

Vol 17, No 1-2 (2015)
Review articles
Published online: 2016-06-30
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The concept of unstable atherosclerotic plaque and pharmacological therapeutic strategies

Karolina Jarząbek, Agata Sobczyk, Wojciech Sobczyk, Krzysztof Łabuzek, Dariusz Belowski, Bożena Gabryel
Chirurgia Polska 2015;17(1-2):49-68.

open access

Vol 17, No 1-2 (2015)
Review articles
Published online: 2016-06-30

Abstract

The main cause of mortality in Poland are diseases of the cardiovascular system. Vascular endothelial dysfunction is the beginning of atherosclerosis development. Atherosclerosis, as an inflammatory process involving the vessel wall, evolves through multiple signaling pathways. While the dyslipidemia accelerate its development. Also, blood flow disorders defined as small and oscillating shear stress through the process of mechanotransduction, increases expression of genes, which are responsible for accumulating deposits in vessel walls. Consequently potentiates free radical reactions. There is still lack of clarity about mechanisms of progression from asymptomatic lesions to unstable plaques with high risk of rapture. Considering so many mechanisms participating in the pathogenesis of atherosclerosis we already have a lot of pharmacological strategies for preventing and treating its complications. This article discusses the main groups of drugs with documented effectiveness in the stabilization of atherosclerotic plaque. There are new opportunities offered by nanodrugs due to an effectiveness increase of the treatment while minimizing its complications by acting directly at the target site.

Abstract

The main cause of mortality in Poland are diseases of the cardiovascular system. Vascular endothelial dysfunction is the beginning of atherosclerosis development. Atherosclerosis, as an inflammatory process involving the vessel wall, evolves through multiple signaling pathways. While the dyslipidemia accelerate its development. Also, blood flow disorders defined as small and oscillating shear stress through the process of mechanotransduction, increases expression of genes, which are responsible for accumulating deposits in vessel walls. Consequently potentiates free radical reactions. There is still lack of clarity about mechanisms of progression from asymptomatic lesions to unstable plaques with high risk of rapture. Considering so many mechanisms participating in the pathogenesis of atherosclerosis we already have a lot of pharmacological strategies for preventing and treating its complications. This article discusses the main groups of drugs with documented effectiveness in the stabilization of atherosclerotic plaque. There are new opportunities offered by nanodrugs due to an effectiveness increase of the treatment while minimizing its complications by acting directly at the target site.

Get Citation

Keywords

unstable atherosclerotic plaque, atherosclerosis, therapeutic strategies, drugs

About this article
Title

The concept of unstable atherosclerotic plaque and pharmacological therapeutic strategies

Journal

Chirurgia Polska (Polish Surgery)

Issue

Vol 17, No 1-2 (2015)

Pages

49-68

Published online

2016-06-30

Bibliographic record

Chirurgia Polska 2015;17(1-2):49-68.

Keywords

unstable atherosclerotic plaque
atherosclerosis
therapeutic strategies
drugs

Authors

Karolina Jarząbek
Agata Sobczyk
Wojciech Sobczyk
Krzysztof Łabuzek
Dariusz Belowski
Bożena Gabryel

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