Evaluation of the serum concentration of selected inflammatory cytokines in patients with carotid artery stenosis

Abstract

Background: The inflammatory process plays an important role in the formation, growth and destabilization of atherosclerotic plaque narrowing the internal carotid artery. The aim of the study was to determine the concentrations of TNF-alpha, interleukin-6 and interleukin-10 in the serum of patients with internal carotid artery stenosis. Another aim was to compare the concentrations of these inflammatory markers in patients with symptomatic and asymptomatic internal carotid artery stenosis.

Material and methods: The study included 65 patients (F/M 20/45; aged 66.29 ± 7.77; 55–80) with symptomatic (39 individuals) or asymptomatic (26 individuals) atherosclerotic internal carotid artery stenosis above 50% on one or both sides. The control group consisted of 30 healthy volunteers (F/M 20/10; aged 61.03 ± 9.08; 50–78).

Results: The mean serum concentration of interleukin-6 was significantly higher both in the group of patients with symptomatic and asymptomatic ICA stenosis, as compared with the control group (p = 0.0002; p = 0.0208, respectively) There were no significant differences in serum concentration of THF-alpha and interleukin-10 between patients and control group.

Conclusions: Patients with atherosclerotic stenosis of the internal carotid artery have shown significantly elevated levels of interleukin-6 in the serum, which suggests that it is involved in the disease process. Cytokines and other inflammatory mediators in patients with carotid artery stenosis require further studies which would allow for a better understanding of the effect on the formation and activity of atherosclerotic lesions.