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Vol 15, No 1 (2013)
Review articles
Published online: 2014-01-08

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Pharmacotherapy of chronic venous disorders according to evidence-based medicine

Jerzy Chudek, Damian Ziaja
Chirurgia Polska 2013;15(1):58-65.


Treatment of chronic venous disorders combines surgical and conservative treatment, which includes compression therapy and pharmacotherapy. The purpose of this paper is to discuss the current regiment of pharmacotherapy regarding chronic venous disorders, which includes the use of venoactive drugs, of which a preparation of micronized diosmin and troxerutin have the best documented beneficial effects. In patients with peripheral edema the use of diu­retics in combined therapy together with a venoactive drug can be recommended in the case of coexisting co-morbidities that increase venous pressure in the lower extremities. Medication accelerating the healing of venous ulcers include preparations of micronized diosmin, aspirin, pentoxifylline, sulodexide and iloprost. Pharmacotherapy should also prevent, or at least decrease the risk of venous ulcer recurrence. Unfortu­nately, as yet no known drug has a documented lowering effect on the rate of venous ulcer recurrence.

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