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Pharmacotherapy of chronic venous disorders according to evidence-based medicine
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Abstract
Treatment of chronic venous disorders combines surgical and conservative treatment, which includes compression therapy and pharmacotherapy. The purpose of this paper is to discuss the current regiment of pharmacotherapy regarding chronic venous disorders, which includes the use of venoactive drugs, of which a preparation of micronized diosmin and troxerutin have the best documented beneficial effects. In patients with peripheral edema the use of diuretics in combined therapy together with a venoactive drug can be recommended in the case of coexisting co-morbidities that increase venous pressure in the lower extremities. Medication accelerating the healing of venous ulcers include preparations of micronized diosmin, aspirin, pentoxifylline, sulodexide and iloprost. Pharmacotherapy should also prevent, or at least decrease the risk of venous ulcer recurrence. Unfortunately, as yet no known drug has a documented lowering effect on the rate of venous ulcer recurrence.
Abstract
Treatment of chronic venous disorders combines surgical and conservative treatment, which includes compression therapy and pharmacotherapy. The purpose of this paper is to discuss the current regiment of pharmacotherapy regarding chronic venous disorders, which includes the use of venoactive drugs, of which a preparation of micronized diosmin and troxerutin have the best documented beneficial effects. In patients with peripheral edema the use of diuretics in combined therapy together with a venoactive drug can be recommended in the case of coexisting co-morbidities that increase venous pressure in the lower extremities. Medication accelerating the healing of venous ulcers include preparations of micronized diosmin, aspirin, pentoxifylline, sulodexide and iloprost. Pharmacotherapy should also prevent, or at least decrease the risk of venous ulcer recurrence. Unfortunately, as yet no known drug has a documented lowering effect on the rate of venous ulcer recurrence.
Keywords
micronized purified flavonoid fraction, Ruscus aculeatus extracts, aescin, troxerutin aspirin, pentoxifylline, sulodexide, iloprost, chronic venous insufficiency, chronic venous disorders
About this articleTitle
Pharmacotherapy of chronic venous disorders according to evidence-based medicine
Journal
Chirurgia Polska (Polish Surgery)
Issue
Pages
58-65
Published online
2014-01-08
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1287
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3262
Bibliographic record
Chirurgia Polska 2013;15(1):58-65.
Keywords
micronized purified flavonoid fraction
Ruscus aculeatus extracts
aescin
troxerutin aspirin
pentoxifylline
sulodexide
iloprost
chronic venous insufficiency
chronic venous disorders
Authors
Jerzy Chudek
Damian Ziaja
