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Efficacy of Solcoseryl in patients with pre-gangrene of lower limbs treated by vascular reconstructive surgery
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Abstract
Material and methods: The study was performed in 60 patients with pre-gangrene of the lower extremities treated by reconstructive vascular surgery. Solcoseryl (20 ml/day) was administered intravenously for 15 days, in addition to routine treatment.
Results: HD-treated patients showed a significant improvement in the Doppler index, nerve conduction, oxymetry and ulcer size. There were no significant differences in the API index between HD-treated and placebo-treated patients. After 2-year follow-up in 18 HD-treated patients, 10 responded to therapy (no claudication), whereas 8 did not (persistent pain or amputation). Of 22 placebo-treated patients, 5 patients responded to therapy and 17 did not.
Conclusions: Intravenous injection of Solcoseryl in patients with pre-gangrene treated by vascular reconstruction accelerates the healing of peripheral necrotic lesions. Intravenous injection of Solcoseryl in patients with pre-gangrene of lower limbs treated by vascular reconstruction increases tissue oxygenation and alleviates the effects of prolonged ischaemia, such as persistent pain in the limb, sensory disturbances and ischaemic neuropathies.
Abstract
Material and methods: The study was performed in 60 patients with pre-gangrene of the lower extremities treated by reconstructive vascular surgery. Solcoseryl (20 ml/day) was administered intravenously for 15 days, in addition to routine treatment.
Results: HD-treated patients showed a significant improvement in the Doppler index, nerve conduction, oxymetry and ulcer size. There were no significant differences in the API index between HD-treated and placebo-treated patients. After 2-year follow-up in 18 HD-treated patients, 10 responded to therapy (no claudication), whereas 8 did not (persistent pain or amputation). Of 22 placebo-treated patients, 5 patients responded to therapy and 17 did not.
Conclusions: Intravenous injection of Solcoseryl in patients with pre-gangrene treated by vascular reconstruction accelerates the healing of peripheral necrotic lesions. Intravenous injection of Solcoseryl in patients with pre-gangrene of lower limbs treated by vascular reconstruction increases tissue oxygenation and alleviates the effects of prolonged ischaemia, such as persistent pain in the limb, sensory disturbances and ischaemic neuropathies.
Keywords
Solcoseryl; critical limb ischaemia; vascular reconstruction


Title
Efficacy of Solcoseryl in patients with pre-gangrene of lower limbs treated by vascular reconstructive surgery
Journal
Chirurgia Polska (Polish Surgery)
Issue
Pages
167-173
Published online
2003-02-10
Bibliographic record
Chirurgia Polska 2002;4(4):167-173.
Keywords
Solcoseryl
critical limb ischaemia
vascular reconstruction
Authors
Zbigniew Markiel
Krzysztof Ziaja
Dariusz Zejc
Jacek Samorodny
Marian Simka
Przemysław Nowakowski
Krzysztof Szaniewski
Wacław Kuczmik