Gastrointestinal stromal tumors (GIST)

Maciej Zaniewski; Zbigniew Smyła; Piotr Piekorz; Joanna Straszecka; Eugeniusz Majewski; Czesław Marcisz; Paweł Jedynak; Krzysztof Nitecki; Zbigniew Antosz

Vol 6, No 4 (2004)

Aktualności

Published online: 2005-01-26

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Gastrointestinal stromal tumors (GIST)

Maciej Zaniewski, Zbigniew Smyła, Piotr Piekorz, Joanna Straszecka, Eugeniusz Majewski, Czesław Marcisz, Paweł Jedynak, Krzysztof Nitecki, Zbigniew Antosz

Chirurgia Polska 2004;6(4):253-259.

Vol 6, No 4 (2004)

Aktualności

Published online: 2005-01-26

Abstract

Gastrointestinal stromal tumors (GIST) originate from the mezenchymal tissue of gastrointestinal tract, most probably from interstitial (Cajal) cells. Being the most common mesenchymal malignancy, GISTs concern no more than 1% of all gastrointestinal neoplasmatic tumors. Stromal tumors appear in the elderly and are usually located in the stomach (70%) and the small intestine (20–30%). About 30% of GISTs are malignant with signs of organ infiltration or with the presence of distant metastases. The presence of the membrane protein KIT (positive reaction against CD 117 in immunohistochemistry) in histological material is the essential factor for the GIST diagnosis. Surgery is the most important method in the treatment of GISTs. The paper presents the authors’ own experience concerning 4 patients with gastrointestinal stromal tumors treated surgically.