open access

Vol 8, No 2 (2006)
Aktualności
Published online: 2006-04-12
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Effective treatment of a patient with critical lower limb ischemia using plasmid encoding vascular endothelial growth factor (pVEGF) - case report

Robert M. Proczka, Maciej Małecki, Katarzyna Gromek, Małgorzata Serafin-Król, Przemysław Janik, Joanna Chorostowska-Wynimko, Jerzy A. Polański
Chirurgia Polska 2006;8(2):164-170.

open access

Vol 8, No 2 (2006)
Aktualności
Published online: 2006-04-12

Abstract

This study describes a really successful trial of angiogenic gene therapy in human beings. We treated a patient with critical limb ischemia using plasmid encoding vascular-endothelial growth factor. The patient before the procedure had rest-pain, nocturnal-pain and necrosis of the left toe. After our therapy the state of the patient systematically got better. A few months post gene transfer, the wound after amputation was healthy, the distance of claudication intermittent elongated and after treatment is about one thousand meters. The only adverse events were spider angiomas and mild edema.

Abstract

This study describes a really successful trial of angiogenic gene therapy in human beings. We treated a patient with critical limb ischemia using plasmid encoding vascular-endothelial growth factor. The patient before the procedure had rest-pain, nocturnal-pain and necrosis of the left toe. After our therapy the state of the patient systematically got better. A few months post gene transfer, the wound after amputation was healthy, the distance of claudication intermittent elongated and after treatment is about one thousand meters. The only adverse events were spider angiomas and mild edema.
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Keywords

gene therapy; ischemic diseases; VEGF

About this article
Title

Effective treatment of a patient with critical lower limb ischemia using plasmid encoding vascular endothelial growth factor (pVEGF) - case report

Journal

Chirurgia Polska (Polish Surgery)

Issue

Vol 8, No 2 (2006)

Pages

164-170

Published online

2006-04-12

Bibliographic record

Chirurgia Polska 2006;8(2):164-170.

Keywords

gene therapy
ischemic diseases
VEGF

Authors

Robert M. Proczka
Maciej Małecki
Katarzyna Gromek
Małgorzata Serafin-Król
Przemysław Janik
Joanna Chorostowska-Wynimko
Jerzy A. Polański

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