Effective treatment of a patient with critical lower limb ischemia using plasmid encoding vascular endothelial growth factor (pVEGF) - case report

Robert M. Proczka; Maciej Małecki; Katarzyna Gromek; Małgorzata Serafin-Król; Przemysław Janik; Joanna Chorostowska-Wynimko; Jerzy A. Polański

Vol 8, No 2 (2006)

Aktualności

Published online: 2006-04-12

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Effective treatment of a patient with critical lower limb ischemia using plasmid encoding vascular endothelial growth factor (pVEGF) - case report

Robert M. Proczka, Maciej Małecki, Katarzyna Gromek, Małgorzata Serafin-Król, Przemysław Janik, Joanna Chorostowska-Wynimko, Jerzy A. Polański

Chirurgia Polska 2006;8(2):164-170.

Vol 8, No 2 (2006)

Aktualności

Published online: 2006-04-12

Abstract

This study describes a really successful trial of angiogenic gene therapy in human beings. We treated a patient with critical limb ischemia using plasmid encoding vascular-endothelial growth factor. The patient before the procedure had rest-pain, nocturnal-pain and necrosis of the left toe. After our therapy the state of the patient systematically got better. A few months post gene transfer, the wound after amputation was healthy, the distance of claudication intermittent elongated and after treatment is about one thousand meters. The only adverse events were spider angiomas and mild edema.