open access
Gene expression profiles in abdominal aortic aneurysm or aortoiliac occlusive disease assessed by cDNA Atlas arrays
open access
Abstract
Material and methods: Specimens of abdominal aorta from 12 patients with AAA, 8 with AIOD and 5 organ donors were used. Total RNA was isolated from aorta tissue and subjected to reverse transcription, then hybridized to Atlas cDNA arrays.
Results: We identified 36 genes (20 from the Atlas Cardiovascular Array and 16 from the Atlas Stress Array) which were significantly differentially expressed in AAA and AIOD.
Conclusions: The results of gene expression profiling in AAA and AIOD indicate the essential role of the genes responsible for inflammation process and extracellular matrix remodelling in both diseases.
Abstract
Material and methods: Specimens of abdominal aorta from 12 patients with AAA, 8 with AIOD and 5 organ donors were used. Total RNA was isolated from aorta tissue and subjected to reverse transcription, then hybridized to Atlas cDNA arrays.
Results: We identified 36 genes (20 from the Atlas Cardiovascular Array and 16 from the Atlas Stress Array) which were significantly differentially expressed in AAA and AIOD.
Conclusions: The results of gene expression profiling in AAA and AIOD indicate the essential role of the genes responsible for inflammation process and extracellular matrix remodelling in both diseases.
Keywords
abdominal aortic aneurysm; aortoiliac occlusive disease; gene expression profiles; Atlas cDNA arrays


Title
Gene expression profiles in abdominal aortic aneurysm or aortoiliac occlusive disease assessed by cDNA Atlas arrays
Journal
Chirurgia Polska (Polish Surgery)
Issue
Pages
149-161
Published online
2008-01-04
Bibliographic record
Chirurgia Polska 2007;9(3):149-161.
Keywords
abdominal aortic aneurysm
aortoiliac occlusive disease
gene expression profiles
Atlas cDNA arrays
Authors
Aleksandra Korcz
Joanna Mikołajczyk-Stecyna
Katarzyna Pawlaczyk
Marcin Gabriel
Grzegorz Oszkinis
Hanna Witucka-Wall
Krzysztof Waliszewski
Ryszard Słomski