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Vol 9, No 3 (2007)
Published online: 2008-01-04
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Gene expression profiles in abdominal aortic aneurysm or aortoiliac occlusive disease assessed by cDNA Atlas arrays

Aleksandra Korcz, Joanna Mikołajczyk-Stecyna, Katarzyna Pawlaczyk, Marcin Gabriel, Grzegorz Oszkinis, Hanna Witucka-Wall, Krzysztof Waliszewski, Ryszard Słomski
Chirurgia Polska 2007;9(3):149-161.

open access

Vol 9, No 3 (2007)
Published online: 2008-01-04

Abstract

Background: Abdominal aortic aneurysms and aortoiliac occlusive disease are the most frequent reasons for vascular surgery procedures within the abdominal cavity. Genetic factors responsible for individual risk of the development of these diseases are little known. The purpose of the present study was to attempt to compare abdominal aortic aneurysm and aortoiliac occlusive disease using the analysis of gene expression profiles with Atlas cDNA arrays.
Material and methods: Specimens of abdominal aorta from 12 patients with AAA, 8 with AIOD and 5 organ donors were used. Total RNA was isolated from aorta tissue and subjected to reverse transcription, then hybridized to Atlas cDNA arrays.
Results: We identified 36 genes (20 from the Atlas Cardiovascular Array and 16 from the Atlas Stress Array) which were significantly differentially expressed in AAA and AIOD.
Conclusions: The results of gene expression profiling in AAA and AIOD indicate the essential role of the genes responsible for inflammation process and extracellular matrix remodelling in both diseases.

Abstract

Background: Abdominal aortic aneurysms and aortoiliac occlusive disease are the most frequent reasons for vascular surgery procedures within the abdominal cavity. Genetic factors responsible for individual risk of the development of these diseases are little known. The purpose of the present study was to attempt to compare abdominal aortic aneurysm and aortoiliac occlusive disease using the analysis of gene expression profiles with Atlas cDNA arrays.
Material and methods: Specimens of abdominal aorta from 12 patients with AAA, 8 with AIOD and 5 organ donors were used. Total RNA was isolated from aorta tissue and subjected to reverse transcription, then hybridized to Atlas cDNA arrays.
Results: We identified 36 genes (20 from the Atlas Cardiovascular Array and 16 from the Atlas Stress Array) which were significantly differentially expressed in AAA and AIOD.
Conclusions: The results of gene expression profiling in AAA and AIOD indicate the essential role of the genes responsible for inflammation process and extracellular matrix remodelling in both diseases.

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Keywords

abdominal aortic aneurysm; aortoiliac occlusive disease; gene expression profiles; Atlas cDNA arrays

About this article
Title

Gene expression profiles in abdominal aortic aneurysm or aortoiliac occlusive disease assessed by cDNA Atlas arrays

Journal

Chirurgia Polska (Polish Surgery)

Issue

Vol 9, No 3 (2007)

Pages

149-161

Published online

2008-01-04

Page views

651

Article views/downloads

1429

Bibliographic record

Chirurgia Polska 2007;9(3):149-161.

Keywords

abdominal aortic aneurysm
aortoiliac occlusive disease
gene expression profiles
Atlas cDNA arrays

Authors

Aleksandra Korcz
Joanna Mikołajczyk-Stecyna
Katarzyna Pawlaczyk
Marcin Gabriel
Grzegorz Oszkinis
Hanna Witucka-Wall
Krzysztof Waliszewski
Ryszard Słomski

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