open access

Vol 9, No 4 (2007)
Published online: 2008-02-12
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Value of proinflammatory cytokines determination and acute phase protein quantity alterations among patients with abdominal aortic aneurysm

Grzegorz Oszkinis, Jacek Kamiński, Marcin Gabriel, Fryderyk Pukacki, Jacek Brzeziński, Magdalena Snoch, Maciej Zieliński, Michał Stanisic, Barbara Kuźnar-Kamińska, Wacław Majewski
Chirurgia Polska 2007;9(4):223-230.

open access

Vol 9, No 4 (2007)
Published online: 2008-02-12

Abstract

Background: Chronic inflammation has a significant role in generating abdominal aortic aneurysms (AAA). It seems that knowledge about these pathomechanisms could have diagnostic and prognostic value.
Material and methods: The study group comprised 49 operated patients with AAA - 39 men and 10 women (79.6% and 20.4% respectively). The study group was divided into subgroups (size and type). There were distinguished three diameter divisions of aneurysm: ≥ 60 mm (48.97%), and 50-60 mm (34.70%) and under 50 mm (16.33%). 39 patients presented symptomatic aneurysm (79.20%), while asymptomatic aneurysm was present in 10 patients (20.40%). The control group was 17 patients with advanced atheromatous changes: 11 men and 6 women (64.70% and 35.30%). Proteins: IL-2, IL-6, IL-10, were examined in the blood sera by the means of an immunoenzymatic ELISH assessment. For CRP level investigation spectrophotometry was used.
Results: A statistically significant increase of the concentration of proteins was assessed - CRP, IL-6 in patients with AAA, comparing with the control group. The concentration of CRP, IL-2, IL-6 differed significantly between groups depending on diameter of the abdominal aortic aneurysm. Patients with symptomatic AAA had a significantly higher concentration of CRP, IL-2, IL-6 than in the group with asymptomatic AAA.
Conclusions: Investigation of the cytokine level (IL-2, IL-6, CRP) can be useful in the monitoring of inflammation changes which can be responsible for aneurysm enlargement. The concentration of inflammation proteins increases with the change of aortic aneurysm diameter. It can be a proof that the enlargement of an aneurysm depends on the intensity of the inflammatory processes. This allows one to take decisions about surgical procedures in appropriate time.

Abstract

Background: Chronic inflammation has a significant role in generating abdominal aortic aneurysms (AAA). It seems that knowledge about these pathomechanisms could have diagnostic and prognostic value.
Material and methods: The study group comprised 49 operated patients with AAA - 39 men and 10 women (79.6% and 20.4% respectively). The study group was divided into subgroups (size and type). There were distinguished three diameter divisions of aneurysm: ≥ 60 mm (48.97%), and 50-60 mm (34.70%) and under 50 mm (16.33%). 39 patients presented symptomatic aneurysm (79.20%), while asymptomatic aneurysm was present in 10 patients (20.40%). The control group was 17 patients with advanced atheromatous changes: 11 men and 6 women (64.70% and 35.30%). Proteins: IL-2, IL-6, IL-10, were examined in the blood sera by the means of an immunoenzymatic ELISH assessment. For CRP level investigation spectrophotometry was used.
Results: A statistically significant increase of the concentration of proteins was assessed - CRP, IL-6 in patients with AAA, comparing with the control group. The concentration of CRP, IL-2, IL-6 differed significantly between groups depending on diameter of the abdominal aortic aneurysm. Patients with symptomatic AAA had a significantly higher concentration of CRP, IL-2, IL-6 than in the group with asymptomatic AAA.
Conclusions: Investigation of the cytokine level (IL-2, IL-6, CRP) can be useful in the monitoring of inflammation changes which can be responsible for aneurysm enlargement. The concentration of inflammation proteins increases with the change of aortic aneurysm diameter. It can be a proof that the enlargement of an aneurysm depends on the intensity of the inflammatory processes. This allows one to take decisions about surgical procedures in appropriate time.
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Keywords

aneurysm; inflammation; cytokins

About this article
Title

Value of proinflammatory cytokines determination and acute phase protein quantity alterations among patients with abdominal aortic aneurysm

Journal

Chirurgia Polska (Polish Surgery)

Issue

Vol 9, No 4 (2007)

Pages

223-230

Published online

2008-02-12

Bibliographic record

Chirurgia Polska 2007;9(4):223-230.

Keywords

aneurysm
inflammation
cytokins

Authors

Grzegorz Oszkinis
Jacek Kamiński
Marcin Gabriel
Fryderyk Pukacki
Jacek Brzeziński
Magdalena Snoch
Maciej Zieliński
Michał Stanisic
Barbara Kuźnar-Kamińska
Wacław Majewski

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