open access
Colon polyps and colon cancer
open access
Abstract
At present some important data concerning apoptosis, proliferation and inflammatory factors in colorectal cancers as well as in polyps have been collected. Recent findings suggest that the quantity of metyloproteinase matrix (MMP-2, MMP-9) and tissue MMP inhibitors (TIMP1 TIMP2) increases together with a cell’s ability to carcinogenesis, reaching the highest levels in adenocarcinomatous tissue. The activity of apoptotic factors (CD95, bcl, bax) is different in hyperplastic polyps, adenomatous polyps and in normal mucosa.
Abstract
At present some important data concerning apoptosis, proliferation and inflammatory factors in colorectal cancers as well as in polyps have been collected. Recent findings suggest that the quantity of metyloproteinase matrix (MMP-2, MMP-9) and tissue MMP inhibitors (TIMP1 TIMP2) increases together with a cell’s ability to carcinogenesis, reaching the highest levels in adenocarcinomatous tissue. The activity of apoptotic factors (CD95, bcl, bax) is different in hyperplastic polyps, adenomatous polyps and in normal mucosa.
Keywords
colon polyp; colon cancer; p53 gen; k-ras gen; apoptosis; inflamation; proliferation


Title
Colon polyps and colon cancer
Journal
Chirurgia Polska (Polish Surgery)
Issue
Pages
30-34
Published online
2008-04-15
Bibliographic record
Chirurgia Polska 2008;10(1):30-34.
Keywords
colon polyp
colon cancer
p53 gen
k-ras gen
apoptosis
inflamation
proliferation
Authors
Iwona Niedzielska
Tomasz Orawczyk
Krzysztof Szaniewski
Krzysztof Ziaja