open access

Vol 10, No 3-4 (2008)
Published online: 2009-05-06
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Metastatic tumours to the spleen - literature review

Dawid Hadasik, Jacek Kostecki, Maciej Zaniewski
Chirurgia Polska 2008;10(3-4):175-180.

open access

Vol 10, No 3-4 (2008)
Published online: 2009-05-06

Abstract

Both primary and metastatic tumours of the spleen are extremely rare phenomena. They are usually diagnosed as a result of autopsy, are not typically large and, in most cases, are accompanied by disseminated cancer disease. The studies show that the frequency of metastatic splenic tumours is estimated at 1-9% of patients. Moreover, they are normally related to metastatic changes localized in the liver and the pancreas. Isolated metastases to the spleen are an even more unique phenomenon and most of such documented cases concern ovarian cancer disease. Although physicians still do not really know the mechanism due to which the spleen seems to be an organ that is relatively resistant to cancer disease metastases, the medical literature describes a couple of theories on this phenomenon. What is emphasized is the role of continuous blood flow through the spleen sinuses which may reduce adhesion of carcinoma cells in the spleen. The presence of humoral substances occurring in the spleen which destroy carcinoma cells could also be a reason for the phenomenon. The intention of the authors of the article is to analyse all information available from medical literature on splenic metastatic tumours, if diagnosed, with regard to their occurrence, frequency and treatment.

Abstract

Both primary and metastatic tumours of the spleen are extremely rare phenomena. They are usually diagnosed as a result of autopsy, are not typically large and, in most cases, are accompanied by disseminated cancer disease. The studies show that the frequency of metastatic splenic tumours is estimated at 1-9% of patients. Moreover, they are normally related to metastatic changes localized in the liver and the pancreas. Isolated metastases to the spleen are an even more unique phenomenon and most of such documented cases concern ovarian cancer disease. Although physicians still do not really know the mechanism due to which the spleen seems to be an organ that is relatively resistant to cancer disease metastases, the medical literature describes a couple of theories on this phenomenon. What is emphasized is the role of continuous blood flow through the spleen sinuses which may reduce adhesion of carcinoma cells in the spleen. The presence of humoral substances occurring in the spleen which destroy carcinoma cells could also be a reason for the phenomenon. The intention of the authors of the article is to analyse all information available from medical literature on splenic metastatic tumours, if diagnosed, with regard to their occurrence, frequency and treatment.
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Keywords

splenic tumours; distant metastasis

About this article
Title

Metastatic tumours to the spleen - literature review

Journal

Chirurgia Polska (Polish Surgery)

Issue

Vol 10, No 3-4 (2008)

Pages

175-180

Published online

2009-05-06

Bibliographic record

Chirurgia Polska 2008;10(3-4):175-180.

Keywords

splenic tumours
distant metastasis

Authors

Dawid Hadasik
Jacek Kostecki
Maciej Zaniewski

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