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Liver transplantation in animal model with transgenic pig’s liver
open access
Abstract
Material and methods: Twenty seven liver transplantations (pig-to-pig) were performed, including 9 cases of transgenic animal transplantation. In the transgenesis, the human α-(1, 2)-fucosyltransferase gene was implemented. After transplantation the clinical conditions of the transplanted animals were followed and pathological studies of the transplanted livers were conducted. To prove the influence of the performed transgenesis, additionally, the human blood extracorporeal perfusion model of the transgenic animal liver was also proposed.
Results: According to the study’s results, the implementation of transgenesis did not result in immunological reaction changes in the pig to pig animal model. However, a limited influence on xenoantibodyrelated rejection reaction in the pig liver perfusion model was observed.
Conclusions: Thus, the results highlight the necessity of further studies as currently, there are no data confirming the possibility to use such transgenic animal organs for liver xenotransplantation.
Polish Surgery 2011, 13, 1, 28–41
Abstract
Material and methods: Twenty seven liver transplantations (pig-to-pig) were performed, including 9 cases of transgenic animal transplantation. In the transgenesis, the human α-(1, 2)-fucosyltransferase gene was implemented. After transplantation the clinical conditions of the transplanted animals were followed and pathological studies of the transplanted livers were conducted. To prove the influence of the performed transgenesis, additionally, the human blood extracorporeal perfusion model of the transgenic animal liver was also proposed.
Results: According to the study’s results, the implementation of transgenesis did not result in immunological reaction changes in the pig to pig animal model. However, a limited influence on xenoantibodyrelated rejection reaction in the pig liver perfusion model was observed.
Conclusions: Thus, the results highlight the necessity of further studies as currently, there are no data confirming the possibility to use such transgenic animal organs for liver xenotransplantation.
Polish Surgery 2011, 13, 1, 28–41
Keywords
liver transplantation; transgenesis; xenotransplantation
About this articleTitle
Liver transplantation in animal model with transgenic pig’s liver
Journal
Chirurgia Polska (Polish Surgery)
Issue
Pages
28-41
Published online
2011-10-19
Page views
658
Article views/downloads
1957
Bibliographic record
Chirurgia Polska 2011;13(1):28-41.
Keywords
liver transplantation
transgenesis
xenotransplantation
Authors
Krzysztof Ziaja
Tomasz Urbanek
Wacław Kuczmik
Marcin Kucharzewski
Grzegorz Biolik
Damian Ziaja
Dariusz Stańczyk
Arkadiusz Krupowies
Jacek Kostyra
Robert Latała
Tomasz Ludyga
Marek Kazibudzki
Jerzy Stojko
Barbara Sidorowicz
Henryka Chmurzewska
