Vol 14, No 1-2 (2012)
Review articles
Published online: 2012-11-19
Biliary complications after orthotopic liver transplantation in adults
Chirurgia Polska 2012;14(1-2):81-94.
Abstract
Liver transplantation has become at present the treatment of choice in cases of end-stage liver disease.
Along with the significant development of transplantology and immunology, the results of liver transplantation
have been gradually improving. Currently, the 5-year survival rate in recipients following orthotopic
liver transplantation (OLT) is at a level of 72–77%, depending on the stage of liver insufficiency.
The presence of complications is inseparably connected with the procedure of liver transplantation, and
occur in 80% of cases during the first six months after OLT. One of the most common are complications
concerning bile ducts. The most important and widely described are bile leakages, anastomotic and nonmagnetyczanastomotic
strictures, bile concrements, sphincter of Oddi dysfunction and compression of the biliary
tract. Such complications are dangerous as many times they lead to the loss of the graft or even death.
Despite permanent improvements in the surgical technique of performing bile ducts anastomoses and
the growing experience of transplantologists, biliary anastomosis is often called the “Achilles heel” of
liver transplantation.
Nowadays, the prevalence of biliary complications is at a level of 6–35% of all liver transplantations, and
most frequently oscillates around 20%, a figure which has been showing a regular downward trend for
many years. The most commonly-listed risk factors of biliary complications after OLT are: preoperative
serum bilirubin level and INR in recipient, T-tube drainage, the number of fresh frozen plasmas used
during the operation and the type of liver graft.
Management options, in cases of suspicion of biliary complications, have also changed with Magnetic
Resonance Cholangiopancreatography (MRCP) having become a “gold standard” in diagnostics. In the
cases of confirmation of the diagnosis of biliary complications, surgical techniques have mainly been
replaced by endoscopic or percutaneous techniques. In cases of the ineffectiveness of the above-mentioned
treatment, liver re-transplantation becomes necessary.
Because of the continuously insufficient number of deceased donors, more and more new methods of
expanding the number of grafts for transplantation are being discovered. The methods of gaining the
grafts from partial hepatectomy from living donors and division of the liver into smaller parts from
a deceased donor have also been introduced.
The aim of this article is to be a review and analysis of reports concerning biliary complications after
orthotopic liver transplantation in adults. This problem has becomes especially important due to more
and more liver transplantations being performed in Poland.
Keywords: liver transplantationbiliary complicationshepatic artery thrombosis