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Efficacy and safety of levosimendan and dobutamine in heart failure: A systematic review and meta-analysis

Milosz J. Jaguszewski, Aleksandra Gasecka, Radoslaw Targonski, Krzysztof J. Filipiak, Lukasz Szarpak
DOI: 10.5603/CJ.a2021.0037
Pubmed: 33843036

open access

Ahead of print
Research letters — Clinical cardiology
Published online: 2021-03-24


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levosimendan; dobutamine; heart failure; intensive care

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Efficacy and safety of levosimendan and dobutamine in heart failure: A systematic review and meta-analysis


Cardiology Journal


Ahead of print

Article type

Research Letter

Published online







heart failure
intensive care


Milosz J. Jaguszewski
Aleksandra Gasecka
Radoslaw Targonski
Krzysztof J. Filipiak
Lukasz Szarpak

References (8)
  1. Pathak A, Lebrin M, Vaccaro A, et al. Pharmacology of levosimendan: inotropic, vasodilatory and cardioprotective effects. J Clin Pharm Ther. 2013; 38(5): 341–349.
  2. Pollesello P, Papp Z. The cardioprotective effects of levosimendan: preclinical and clinical evidence. J Cardiovasc Pharmacol. 2007; 50(3): 257–263.
  3. Harjola VP, Giannakoulas G, von Lewinski D, et al. Use of levosimendan in acute heart failure. Eur Heart J Suppl. 2018; 20(Suppl I): I2–II10.
  4. Yaman M, Arslan U, Kaya A, et al. Levosimendan accelerates recovery in patients with takotsubo cardiomyopathy. Cardiol J. 2016; 23(6): 610–615.
  5. Bayram M, De Luca L, Massie MB, et al. Reassessment of dobutamine, dopamine, and milrinone in the management of acute heart failure syndromes. Am J Cardiol. 2005; 96(6A): 47G–58G.
  6. Slawsky MT, Colucci WS, Gottlieb SS, et al. Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators. Circulation. 2000; 102(18): 2222–2227.
  7. Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005; 5: 13.
  8. Tycińska A, Gierlotka M, Bugajski J, et al. Levosimendan in the treatment of patients with acute cardiac conditions: an expert opinion of the Association of Intensive Cardiac Care of the Polish Cardiac Society. Kardiol Pol. 2020; 78(7-8): 825–834.

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