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Vol 25, No 1 (2021)
Original paper
Published online: 2021-03-15
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Myeloperoxidase (MPO) and high sensitivity C-reactive protein (hsCRP) as inflammatory biomarkers of endothelial and leukocyte activation in overweight hypertensive patients

Dunja Buljubasic1, Ines Drenjancevic2, Aleksandar Kibel32, Lada Zibar45, Vedrana Vizjak6, Sanja Mandic78, Tatjana Bacun910
DOI: 10.5603/AH.a2021.0003
·
Arterial Hypertension 2021;25(1):15-21.
Affiliations
  1. Department of Nephrology and Dialysis, Internal Medicine Clinic, Osijek University Hospital Centre, Osijek, Croatia
  2. Department of Physiology and Immunology, Faculty of Medicine, University Josip Juraj Strossmayer in Osijek, Osijek, Croatia
  3. Department of Heart and Vascular Diseases, Internal Medicine Clinic, Osijek University Hospital Centre, Osijek, Croatia
  4. Department of Nephrology, Clinical Hospital Merkur, Zagreb, Croatia
  5. Department of Pathophysiology, Faculty of Medicine, University Josip Juraj Strossmayer, Osijek, Croatia
  6. Department of Medicine Zulekha Hospital Sharjah, United Arab Emirates
  7. Department for Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, University Josip Juraj Strossmayer, Osijek, Croatia
  8. Department of Clinical Laboratory Diagnostics, Osijek University Hospital Centre, Osijek, Croatia
  9. Department of Internal Medicine, Faculty of Medicine, University Josip Juraj Strossmayer Osijek, Croatia
  10. Department of Endocrinology and Metabolic Disease, Internal Medicine Clinic, Osijek University Hospital Centre, Osijek, Croatia

open access

Vol 25, No 1 (2021)
ORIGINAL PAPERS
Published online: 2021-03-15

Abstract

Background: Low-grade inflammation mediates the relation between overweight and the development of cardiovascular diseases. The study aimed to examine if myeloperoxidase (MPO) and hsCRP (high-sensitivity C-reactive protein) in overweight hypertensive patients can be used as biomarkers of endothelial and leukocyte activation.

Material and methods: Seventy-five subjects were included in the study; 38 had essential arterial hypertension (AH) and 37 were normotensive controls (NC), subsequently divided into overweight (OW; BMI ≥ 25 kg/m2) and normal weight subgroups (NW; BMI < 25 kg/m2). Body mass index (BMI), inflammatory markers concentrations, association of MPO and hsCRP with AH and/or overweight were assessed.

Results: AH patients had higher MPO (median 132.5 pmol/L, IQR: 53.8–691.9) (p < 0.001), while hsCRP did not significantly differ compared to normotensive controls (NC). NW-AH patients had higher MPO (p = 0.02) than normotensive NW patients. MPO was similar between normotensive patients OW and NW, while hsCRP concentration was significantly higher in the OW (median 1.85 mg/L, IQR: 0.47–7.19) (p = 0.01) compared to NW. OW-AH patients had significantly higher MPO (median 137.4 pmol/L, IQR: 53.80–703.4) (p = 0.002) compared to normotensive NW and OW (p < 0.001) patients, likely reflecting neutrophilic activation in hypertension. Additionaly, OW-AH patients had significantly higher hsCRP (median 1.71 mg/L, IQR: 0.22–14) (p = 0.005) than normotensive NW patients. hsCRP significantly positively correlated with BMI in both AH (r = 0.41, p = 0.009) and NC groups (r = 0.38, p = 0.01), while MPO did not correlate, supporting inflammation in OW, particularly in OW with AH.

Conclusions: All together, the results suggest that inflammation may mediate mutual association of AH and OW, suggesting MPO as inflammatory biomarker for AH and hsCRP for overweight.

Abstract

Background: Low-grade inflammation mediates the relation between overweight and the development of cardiovascular diseases. The study aimed to examine if myeloperoxidase (MPO) and hsCRP (high-sensitivity C-reactive protein) in overweight hypertensive patients can be used as biomarkers of endothelial and leukocyte activation.

Material and methods: Seventy-five subjects were included in the study; 38 had essential arterial hypertension (AH) and 37 were normotensive controls (NC), subsequently divided into overweight (OW; BMI ≥ 25 kg/m2) and normal weight subgroups (NW; BMI < 25 kg/m2). Body mass index (BMI), inflammatory markers concentrations, association of MPO and hsCRP with AH and/or overweight were assessed.

Results: AH patients had higher MPO (median 132.5 pmol/L, IQR: 53.8–691.9) (p < 0.001), while hsCRP did not significantly differ compared to normotensive controls (NC). NW-AH patients had higher MPO (p = 0.02) than normotensive NW patients. MPO was similar between normotensive patients OW and NW, while hsCRP concentration was significantly higher in the OW (median 1.85 mg/L, IQR: 0.47–7.19) (p = 0.01) compared to NW. OW-AH patients had significantly higher MPO (median 137.4 pmol/L, IQR: 53.80–703.4) (p = 0.002) compared to normotensive NW and OW (p < 0.001) patients, likely reflecting neutrophilic activation in hypertension. Additionaly, OW-AH patients had significantly higher hsCRP (median 1.71 mg/L, IQR: 0.22–14) (p = 0.005) than normotensive NW patients. hsCRP significantly positively correlated with BMI in both AH (r = 0.41, p = 0.009) and NC groups (r = 0.38, p = 0.01), while MPO did not correlate, supporting inflammation in OW, particularly in OW with AH.

Conclusions: All together, the results suggest that inflammation may mediate mutual association of AH and OW, suggesting MPO as inflammatory biomarker for AH and hsCRP for overweight.

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Keywords

arterial hypertension; overweight; myeloperoxidase; high sensitivity C-reactive protein; inflammation; biomarker

About this article
Title

Myeloperoxidase (MPO) and high sensitivity C-reactive protein (hsCRP) as inflammatory biomarkers of endothelial and leukocyte activation in overweight hypertensive patients

Journal

Arterial Hypertension

Issue

Vol 25, No 1 (2021)

Article type

Original paper

Pages

15-21

Published online

2021-03-15

Page views

854

Article views/downloads

676

DOI

10.5603/AH.a2021.0003

Bibliographic record

Arterial Hypertension 2021;25(1):15-21.

Keywords

arterial hypertension
overweight
myeloperoxidase
high sensitivity C-reactive protein
inflammation
biomarker

Authors

Dunja Buljubasic
Ines Drenjancevic
Aleksandar Kibel
Lada Zibar
Vedrana Vizjak
Sanja Mandic
Tatjana Bacun

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