Effect of achieving blood pressure targets on the relative telomere length in hypertensive patients with and without type 2 diabetes mellitus
Abstract
Background. The role of relative telomere length (RTL) as a marker of cardiovascular prognosis and quality control
of the disease course remains to be found out. The aim of the study was to determine the relationship between
the relative blood leukocyte telomere length (RLTL), relative buccal epithelium cell telomere length (RBTL) and
achieving blood pressure targets (BPTs) in hypertensive (H) individuals with type 2 diabetes mellitus (T2DM) and
without T2DM.
Material and methods. In 156 patients with stage II hypertension (96 of them had T2DM), carbohydrate metabolism
parameters and blood pressure levels were evaluated. RLTL and RBTL were determined by a real time
quantitative PCR.
Results. A combination of hypertension and T2DM was associated with significantly greater RLTL (p = 0.009) and
RBTL (p = 0.001) compared with isolated hypertension. There was no convincing evidence of BPT influence on
the change in the RLTL in isolated hypertension. Achieving BP targets was associated with a paradoxical shortening
of RBTL. There was a significant shortening of RTL in hypertensive patients with T2DM when the BPTs were not
reached. An analysis of variance revealed a significant influence of BPTs on the RBTL and RLTL.
Conclusion. Patients with a comorbid course of hypertension and T2DM had more pronounced decrease in the
RTL. Target levels of blood pressure have a more significant effect on the RLT than the glycemic control in patients
with concomitant T2DM. An additional determination of the RBTL enhances the diagnostic and prognostic power
when evaluating the effectiveness of correcting cardiovascular risk factors including blood pressure.
Keywords: hypertensiontype 2 diabetes mellitusrelative telomere lengthcardiovascular risk factors
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