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Vol 23, No 3 (2019)
Original paper
Published online: 2019-09-12
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Relations of angiotensin-(1-7) with hemodynamic and cardiac structural and functional parameters in patients with hypertension and type 2 diabetes

Sergiy M. Koval1, Kostiantyn O. Yushko1, Iryna O. Snihurska1, Tetyana G. Starchenko1, Volodymyr I. Pankiv2, Olga M. Lytvynova3, Olga V. Mysnychenko1
DOI: 10.5603/AH.a2019.0012
·
Arterial Hypertension 2019;23(3):183-189.
Affiliations
  1. Department of Arterial Hypertension and Prevention of Its Complications, L.T. Mala National Institute of Therapy of the NAMN Ukraine, State Institution, Kharkiv, Ukraine
  2. Department of Preventive Endocrinology, Ukrainian Scientific and Practical Center of Endocrine Surgery, Kyiv, Ukraine
  3. Department of Laboratory Diagnostics, National University of Pharmacy, Kharkiv, Ukraine

open access

Vol 23, No 3 (2019)
ORIGINAL PAPERS
Published online: 2019-09-12

Abstract

Background. The angiotensin-(1-7) is a new component of the renin-angiotensin system, the product of the degradation of angiotensin II and its functional antagonist, but its role in hypertension with type 2 diabetes (T2D) is not clear. The aim of the study was to investigate the levels of angiotensin-(1-7) in patients with hypertension and T2D and determine its relations to hemodynamic and cardiac structural and functional parameters.

Material and methods. We examined 70 patients with hypertension and T2D. Investigation protocol included physical examination, standard transthoracic echocardiography and determination of the angiotensin-(1-7) blood levels by ELISA. Control group consisted of 16 healthy volunteers.

Results. The angiotensin-(1-7) levels in observed patients were significantly lower than in volunteers [105.51 (89.13;121.17) ng/L vs. 132.75 (125.06; 142.87) ng/L, p < 0.001]. The levels of the angiotensin-(1-7) significantly negatively correlated with duration of hypertension (r = –0.29, p < 0.05), systolic blood pressure (BP) (r = –0.38, p < 0.05), diastolic BP (r = –0.36, p < 0.01), average BP (r = –0.32, p < 0.01), left ventricular (LV) internal dimension at end-diastole (r = –0.37, p < 0.01), LV mass (r = –0.40, p < 0.001), LV mass index (r = –0.41, p < 0.001). In patients with LV hypertrophy, angiotensin-(1-7) levels were significantly lower than in patients without LV hypertrophy [101.9 (88.2; 117.7) ng/L vs. 129.3 (117.5; 136.8) ng/L, p < 0.01] and in patients with diastolic LV dysfunction — lower than in the patients with normal diastolic function [101.1 (87.9; 116.6) ng/L vs. 121.1 (105.5; 128.9) ng/L, p < 0.01].

Conclusions. The angiotensin-(1-7) can be considered as an important pathogenetic factor in the development of hypertension with T2D, a BP regulator and a cardioprotective agent that prevents the development of remodeling and diastolic dysfunction of the LV.

Abstract

Background. The angiotensin-(1-7) is a new component of the renin-angiotensin system, the product of the degradation of angiotensin II and its functional antagonist, but its role in hypertension with type 2 diabetes (T2D) is not clear. The aim of the study was to investigate the levels of angiotensin-(1-7) in patients with hypertension and T2D and determine its relations to hemodynamic and cardiac structural and functional parameters.

Material and methods. We examined 70 patients with hypertension and T2D. Investigation protocol included physical examination, standard transthoracic echocardiography and determination of the angiotensin-(1-7) blood levels by ELISA. Control group consisted of 16 healthy volunteers.

Results. The angiotensin-(1-7) levels in observed patients were significantly lower than in volunteers [105.51 (89.13;121.17) ng/L vs. 132.75 (125.06; 142.87) ng/L, p < 0.001]. The levels of the angiotensin-(1-7) significantly negatively correlated with duration of hypertension (r = –0.29, p < 0.05), systolic blood pressure (BP) (r = –0.38, p < 0.05), diastolic BP (r = –0.36, p < 0.01), average BP (r = –0.32, p < 0.01), left ventricular (LV) internal dimension at end-diastole (r = –0.37, p < 0.01), LV mass (r = –0.40, p < 0.001), LV mass index (r = –0.41, p < 0.001). In patients with LV hypertrophy, angiotensin-(1-7) levels were significantly lower than in patients without LV hypertrophy [101.9 (88.2; 117.7) ng/L vs. 129.3 (117.5; 136.8) ng/L, p < 0.01] and in patients with diastolic LV dysfunction — lower than in the patients with normal diastolic function [101.1 (87.9; 116.6) ng/L vs. 121.1 (105.5; 128.9) ng/L, p < 0.01].

Conclusions. The angiotensin-(1-7) can be considered as an important pathogenetic factor in the development of hypertension with T2D, a BP regulator and a cardioprotective agent that prevents the development of remodeling and diastolic dysfunction of the LV.

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Keywords

angiotensin-(1-7); hypertension; type 2 diabetes; left ventricular remodeling; diastolic dysfunction

About this article
Title

Relations of angiotensin-(1-7) with hemodynamic and cardiac structural and functional parameters in patients with hypertension and type 2 diabetes

Journal

Arterial Hypertension

Issue

Vol 23, No 3 (2019)

Article type

Original paper

Pages

183-189

Published online

2019-09-12

Page views

986

Article views/downloads

763

DOI

10.5603/AH.a2019.0012

Bibliographic record

Arterial Hypertension 2019;23(3):183-189.

Keywords

angiotensin-(1-7)
hypertension
type 2 diabetes
left ventricular remodeling
diastolic dysfunction

Authors

Sergiy M. Koval
Kostiantyn O. Yushko
Iryna O. Snihurska
Tetyana G. Starchenko
Volodymyr I. Pankiv
Olga M. Lytvynova
Olga V. Mysnychenko

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