Vol 22, No 3 (2018)
REVIEW
Published online: 2018-09-28
Cardiac troponin measured by a high-sensitivity assay in hypertensive patients
DOI: 10.5603/AH.2018.0014
Arterial Hypertension 2018;22(3):107-112.
Abstract
Thanks to the rapid advances in laboratory techniques sensitive assays for measurement of cardiac troponin level have been recently introduced, and now is possible to determine ten-fold lower concentration of troponin in blood serum than the standard method used until now. The blood level of highly sensitive cardiac troponin in hypertensive patients is higher than in healthy persons, which may indicate increased necrosis or apoptosis of cardiac cells. Elevated high-sensitivity cardiac troponin concentration is an important risk factor for future cardiovascular complications independent of many co-existing contributing factors. In particular, elevated concentration of this troponin indicates the left ventricular hypertrophy and a tendency to develop heart failure. It has also been shown that elevated concentrations of high-sensitivity troponin are more common in non-dipper patients than in those with a normal circadian pattern of blood pressure. Few studies so far indicate that currently used antihypertensive therapy only slightly lower the increase concentration of those compounds in serum.
Keywords: cardiac troponinhypertensive patients
References
- Szczeklik A. Choroby Wewnętrzne. Medycyna Praktyczna, Kraków 2010.
- Willeit P, Welsh P, Evans JDW, et al. High-Sensitivity Cardiac Troponin Concentration and Risk of First-Ever Cardiovascular Outcomes in 154,052 Participants. J Am Coll Cardiol. 2017; 70(5): 558–568.
- Setsuta K, Kitahara Y, Arae M, et al. Elevated cardiac troponin T predicts adverse outcomes in hypertensive patients. Int Heart J. 2011; 52(3): 164–169.
- Sato Y, Yamamoto E, Sawa T, et al. High-sensitivity cardiac troponin T in essential hypertension. J Cardiol. 2011; 58(3): 226–231.
- McEvoy J, Chen Y, Nambi V, et al. High-Sensitivity Cardiac Troponin T and Risk of HypertensionCLINICAL PERSPECTIVE. Circulation. 2015; 132(9): 825–833.
- Aeschbacher S, Schoen T, Bossard M, et al. Relationship between high-sensitivity cardiac troponin I and blood pressure among young and healthy adults. Am J Hypertens. 2015; 28(6): 789–796.
- Askin L, Yesiltepe Y. High-Sensitivity Cardiac Troponin T levels in prehypertensive patients. Clin Exp Hypertens. 2018; 40(4): 332–336.
- Askin L, Tasolar H, Aksu U, et al. Discerning the relationship between left ventricular geometry, high-sensitivity troponin T, and nondipper hypertension. Blood Press Monit. 2018; 23(1): 12–18.
- Çaylı M, Gür M, Elbasan Z, et al. High-sensitivity cardiac troponin T predicts nondipper hypertension in newly diagnosed hypertensive patients. J Clin Hypertens (Greenwich). 2013; 15(10): 731–736.
- Hitsumoto T. Arterial Velocity Pulse Index as a Novel Marker of Atherosclerosis Using Pulse Wave Analysis on High Sensitivity Troponin T in Hypertensive Patients. Cardiol Res. 2017; 8(2): 36–43.
- Jaroch J, Rzyczkowska B, Bociąga Z, et al. The relationship of carotid arterial stiffness to left ventricular diastolic dysfunction in untreated hypertension. Kardiol Pol. 2012; 70(3): 223–231.
- Hitsumoto T, Shirai K. Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients. Diabetes Metab Syndr Obes. 2015; 8: 157–162.
- Sugiura T, Dohi Y, Takase H, et al. Differential effects of brachial and central blood pressures on circulating levels of high-sensitivity cardiac troponin I in the general population. Atherosclerosis. 2018; 269: 185–191.
- Pokharel Y, Sun W, de Lemos JA, et al. High-sensitivity troponin T and cardiovascular events in systolic blood pressure categories: atherosclerosis risk in communities study. Hypertension. 2015; 65(1): 78–84.
- Kaypakli O, Gür M, Gözükara MY, et al. Association between high-sensitivity troponin T, left ventricular hypertrophy, and myocardial performance index. Herz. 2015; 40(7): 1004–1010.
- Miao DM, Zhang LP, Yu HP, et al. Serum levels of high-sensitivity troponin T: a novel marker for left ventricular remodeling and performance in hypertensive subjects. Genet Mol Res. 2014; 13(3): 5143–5153.
- Gravning J, Askevold ET, Nymo SH, et al. CORONA Study Group. Prognostic effect of high-sensitive troponin T assessment in elderly patients with chronic heart failure: results from the CORONA trial. Circ Heart Fail. 2014; 7(1): 96–103.
- Aimo A, Januzzi JL, Vergaro G, et al. Prognostic Value of High-Sensitivity Troponin T in Chronic Heart Failure: An Individual Patient Data Meta-Analysis. Circulation. 2018; 137(3): 286–297.
- Koenig W, Breitling LP, Hahmann H, et al. Cardiac troponin T measured by a high-sensitivity assay predicts recurrent cardiovascular events in stable coronary heart disease patients with 8-year follow-up. Clin Chem. 2012; 58(8): 1215–1224.
- Korff S, Katus HA, Giannitsis E. Differential diagnosis of elevated troponins. Heart. 2006; 92(7): 987–993.
- Kociol RD, Pang PS, Gheorghiade M, et al. Troponin elevation in heart failure prevalence, mechanisms, and clinical implications. J Am Coll Cardiol. 2010; 56(14): 1071–1078.
- Moliner P, Lupón J, Barallat J, et al. TTM study group, ADHERE Investigators. Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma. J Trauma. 2000; 48(5): 924–931.
- Fortuño MA, Ravassa S, Fortuño A, et al. Cardiomyocyte apoptotic cell death in arterial hypertension: mechanisms and potential management. Hypertension. 2001; 38(6): 1406–1412.
- Yue TL, Ohlstein EH, Ruffolo RR. Apoptosis: a potential target for discovering novel therapies for cardiovascular diseases. Curr Opin Chem Biol. 1999; 3(4): 474–480.
- Hoshide S, Fukutomi M, Eguchi K, et al. Change in high-sensitive cardiac troponin T on hypertensive treatment. Clin Exp Hypertens. 2013; 35(1): 40–44.
- Jagodzinski A, Neumann JT, Ojeda F, et al. Cardiovascular Biomarkers in Hypertensive Patients with Medical Treatment-Results from the Randomized TEAMSTA Protect I Trial. Clin Chem. 2017; 63(12): 1877–1885.
- Tünerir B, Colak O, Alataş O, et al. Measurement of troponin T to detect cardioprotective effect of trimetazidine during coronary artery bypass grafting. Ann Thorac Surg. 1999; 68(6): 2173–2176.
- Di Napoli P, Di Giovanni P, Gaeta MA, et al. Beneficial effects of trimetazidine treatment on exercise tolerance and B-type natriuretic peptide and troponin T plasma levels in patients with stable ischemic cardiomyopathy. Am Heart J. 2007; 154(3): 602.e1–602.e5.