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Vol 20, No 4 (2016)
ORIGINAL PAPERS
Published online: 2016-12-29
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A beneficial effect of estradiol on blood pressure, not on glucose and lipids levels in women with Turner syndrome

Tomasz Jerzy Irzyniec, Wacław Jeż
DOI: 10.5603/AH.2016.0023
·
Arterial Hypertension 2016;20(4):206-210.

open access

Vol 20, No 4 (2016)
ORIGINAL PAPERS
Published online: 2016-12-29

Abstract

Introduction. Turner syndrome (TS) is the form of gonadal malfunction. Arterial hypertension, elevated LDL and glucose and decreased HDL levels are characteristic of TS-women. Hormone therapy is a treatment for short stature and sex hormone deficits. Hormonal replacement therapy (HRT) reduces the risk of cardiovascular diseases. A large percentage of TS-women do not comply with doctors’ orders regarding HRT.

The analysis of 17β estradiol (E2) levels and the assessment of blood pressure, lipid and carbohydrate metabolisms in TS-women it is possible to state whether HRT decreases the risk of cardiovascular diseases?

Material and methods. The group of 95 TS-women, who declared HRT, were investigated. The information about HRT was collected during the anamnesis. E2, total cholesterol (TC), high (HDL) and low (LDL) density lipoproteins, triglycerides (TG) and glucose were assessed. Patients were divided into subgroups with E2 ≥ 110 pmol/L (n = 34) (HE) and < 110 pmol/L (n = 61) (LE) respectively.

Results. Arterial hypertension was diagnosed in 26.3%. The groups did not differ in systolic 119 ± 20 versus 118 ± 14 and diastolic 82 ± 13 versus 80 ± 10 mm Hg blood pressure. Despite the higher concentrations of E2 in HE, no differences were found in weights, lipids and glucose concentrations. Negative correlations between E2 and body mass (r = –0.25, p = 0.04) and diastolic blood pressure (r = –0.28, p = 0.02) as well as positive between E2 and glucose (r = 0.24, p < 0.05) were observed only in HE. No correlations between E2 and lipids were found.

Conclusions. 1. Only 1/3 TS-women, who declare HRT, have a satisfactory level of E2.

  1. In TS-women HRT does not affect glucose and lipid metabolisms.

3. Negative correlation between E2 and diastolic blood pressure in TS-women suggest beneficial effect of estrogens in hypertension.

Abstract

Introduction. Turner syndrome (TS) is the form of gonadal malfunction. Arterial hypertension, elevated LDL and glucose and decreased HDL levels are characteristic of TS-women. Hormone therapy is a treatment for short stature and sex hormone deficits. Hormonal replacement therapy (HRT) reduces the risk of cardiovascular diseases. A large percentage of TS-women do not comply with doctors’ orders regarding HRT.

The analysis of 17β estradiol (E2) levels and the assessment of blood pressure, lipid and carbohydrate metabolisms in TS-women it is possible to state whether HRT decreases the risk of cardiovascular diseases?

Material and methods. The group of 95 TS-women, who declared HRT, were investigated. The information about HRT was collected during the anamnesis. E2, total cholesterol (TC), high (HDL) and low (LDL) density lipoproteins, triglycerides (TG) and glucose were assessed. Patients were divided into subgroups with E2 ≥ 110 pmol/L (n = 34) (HE) and < 110 pmol/L (n = 61) (LE) respectively.

Results. Arterial hypertension was diagnosed in 26.3%. The groups did not differ in systolic 119 ± 20 versus 118 ± 14 and diastolic 82 ± 13 versus 80 ± 10 mm Hg blood pressure. Despite the higher concentrations of E2 in HE, no differences were found in weights, lipids and glucose concentrations. Negative correlations between E2 and body mass (r = –0.25, p = 0.04) and diastolic blood pressure (r = –0.28, p = 0.02) as well as positive between E2 and glucose (r = 0.24, p < 0.05) were observed only in HE. No correlations between E2 and lipids were found.

Conclusions. 1. Only 1/3 TS-women, who declare HRT, have a satisfactory level of E2.

  1. In TS-women HRT does not affect glucose and lipid metabolisms.

3. Negative correlation between E2 and diastolic blood pressure in TS-women suggest beneficial effect of estrogens in hypertension.

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Keywords

Turner syndrome, arterial hypertension, estradiol, carbohydrates, lipids

About this article
Title

A beneficial effect of estradiol on blood pressure, not on glucose and lipids levels in women with Turner syndrome

Journal

Arterial Hypertension

Issue

Vol 20, No 4 (2016)

Pages

206-210

Published online

2016-12-29

DOI

10.5603/AH.2016.0023

Bibliographic record

Arterial Hypertension 2016;20(4):206-210.

Keywords

Turner syndrome
arterial hypertension
estradiol
carbohydrates
lipids

Authors

Tomasz Jerzy Irzyniec
Wacław Jeż

References (20)
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