dostęp otwarty

Tom 20, Nr 4 (2016)
REVIEW
Opublikowany online: 2016-12-29
Pobierz cytowanie

Arterial hypertension, obesity and non-alcoholic fatty liver disease: is there any connection?

Nataliia Vitaliivna Kuzminova, Olena Viktorivna Gribenyuk, Nataliia Yuriivna Osovska, Iryna Ivanivna Knyazkova
DOI: 10.5603/AH.2016.0025
·
Arterial Hypertension 2016;20(4):216-227.

dostęp otwarty

Tom 20, Nr 4 (2016)
REVIEW
Opublikowany online: 2016-12-29

Streszczenie

The combination of hypertension, obesity and non-alcoholic fatty liver disease occurs in medical practice very often. A number of studies have shown that non-alcoholic fatty liver disease increases the risk of cardiovascular disease independently of other predictors and manifestations of the metabolic syndrome. Current issues of research and identification of common pathogenic relationships of obesity, hypertension, and liver steatosis are investigated in the article. According to the analysed literature, it is indicated that insulin resistance and compensatory hyperinsulinaemia are considered as one of the key factors in the development of this comorbidity. The processes of chronic inflammation are increasing with the growth of adipose tissue volume. Some researchers believe that non-specific systemic inflammation combines arterial hypertension, increased body weight (especially abdominal obesity), steatosis, dyslipidaemia, atherogenesis and arteriosclerosis into a single syndrome. The role of non-alcoholic fatty liver disease in the growth of the thickness of the intima-media complex was studied. It is known that adipose tissue functions as an endocrine organ, expresses genes encoding bioactive substances, and secretes certain cytokines. A strong link between dysfunction of adipose tissue in patients with non-alcoholic fatty liver disease and in such conditions as metabolic syndrome and cardiovascular disease was demonstrated. The dysfunction of the endothelium is also advisable to consider as the connecting link between liver disease, obesity and hypertension. Despite some understanding of common pathogenic mechanisms for the development of non-alcoholic fatty liver disease and hypertension, this comorbid pathology remains the subject of much debate and a variety of studies.

Streszczenie

The combination of hypertension, obesity and non-alcoholic fatty liver disease occurs in medical practice very often. A number of studies have shown that non-alcoholic fatty liver disease increases the risk of cardiovascular disease independently of other predictors and manifestations of the metabolic syndrome. Current issues of research and identification of common pathogenic relationships of obesity, hypertension, and liver steatosis are investigated in the article. According to the analysed literature, it is indicated that insulin resistance and compensatory hyperinsulinaemia are considered as one of the key factors in the development of this comorbidity. The processes of chronic inflammation are increasing with the growth of adipose tissue volume. Some researchers believe that non-specific systemic inflammation combines arterial hypertension, increased body weight (especially abdominal obesity), steatosis, dyslipidaemia, atherogenesis and arteriosclerosis into a single syndrome. The role of non-alcoholic fatty liver disease in the growth of the thickness of the intima-media complex was studied. It is known that adipose tissue functions as an endocrine organ, expresses genes encoding bioactive substances, and secretes certain cytokines. A strong link between dysfunction of adipose tissue in patients with non-alcoholic fatty liver disease and in such conditions as metabolic syndrome and cardiovascular disease was demonstrated. The dysfunction of the endothelium is also advisable to consider as the connecting link between liver disease, obesity and hypertension. Despite some understanding of common pathogenic mechanisms for the development of non-alcoholic fatty liver disease and hypertension, this comorbid pathology remains the subject of much debate and a variety of studies.

Pobierz cytowanie

Słowa kluczowe

arterial hypertension, obesity, non-alcoholic fatty liver disease, insulin resistance, dyslipidaemia, non-specific systemic inflammation, endothelial dysfunction, atherogenesis

Informacje o artykule
Tytuł

Arterial hypertension, obesity and non-alcoholic fatty liver disease: is there any connection?

Czasopismo

Arterial Hypertension

Numer

Tom 20, Nr 4 (2016)

Strony

216-227

Data publikacji on-line

2016-12-29

DOI

10.5603/AH.2016.0025

Rekord bibliograficzny

Arterial Hypertension 2016;20(4):216-227.

Słowa kluczowe

arterial hypertension
obesity
non-alcoholic fatty liver disease
insulin resistance
dyslipidaemia
non-specific systemic inflammation
endothelial dysfunction
atherogenesis

Autorzy

Nataliia Vitaliivna Kuzminova
Olena Viktorivna Gribenyuk
Nataliia Yuriivna Osovska
Iryna Ivanivna Knyazkova

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