open access

Vol 19, No 4 (2015)
Artykuły redakcyjne
Published online: 2015-12-31
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Telmisartan in the treatment of hypertension — optimal choice according to guidelines PTNT 2015

Krystyna Widecka
DOI: 10.5603/AH.2015.0019
·
Arterial Hypertension 2015;19(4):145-151.

open access

Vol 19, No 4 (2015)
Artykuły redakcyjne
Published online: 2015-12-31

Abstract

In recent years emphasis in the treatment of hypertension has been put on the individualization of treatment. The recently published guidelines of the Polish Society of Hypertension list several clinical situations in which use of angiotensin II receptor blockers (ARBs) is indicated. Blockade of the renin-angiotensin- aldosterone system plays a pivotal role in the treatment of high blood pressure and prevention of target organ damage. Telmisartan is an angiotensin II receptor blocker displaying beneficial unique pharmacologic properties, metabolic effects, antihypertensive efficacy in monotherapy and combinations and good tolerance. Clinical studies confirm that telmisartan improves endothelial function, insulin sensitivity and lipid profiles, reduces arterial stiffness. In addition, telmisartan improves renal function and has potential beneficial effects on prevention of cerebrovascular disease. The Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET) study has shown that telmisartan provides similar cardiovascular protection to ramipril in high-risk patients, while being better tolerated.

Abstract

In recent years emphasis in the treatment of hypertension has been put on the individualization of treatment. The recently published guidelines of the Polish Society of Hypertension list several clinical situations in which use of angiotensin II receptor blockers (ARBs) is indicated. Blockade of the renin-angiotensin- aldosterone system plays a pivotal role in the treatment of high blood pressure and prevention of target organ damage. Telmisartan is an angiotensin II receptor blocker displaying beneficial unique pharmacologic properties, metabolic effects, antihypertensive efficacy in monotherapy and combinations and good tolerance. Clinical studies confirm that telmisartan improves endothelial function, insulin sensitivity and lipid profiles, reduces arterial stiffness. In addition, telmisartan improves renal function and has potential beneficial effects on prevention of cerebrovascular disease. The Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET) study has shown that telmisartan provides similar cardiovascular protection to ramipril in high-risk patients, while being better tolerated.

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Keywords

telmisartan, angiotensin II receptor blockers, hypertension, guidelines

About this article
Title

Telmisartan in the treatment of hypertension — optimal choice according to guidelines PTNT 2015

Journal

Arterial Hypertension

Issue

Vol 19, No 4 (2015)

Pages

145-151

Published online

2015-12-31

DOI

10.5603/AH.2015.0019

Bibliographic record

Arterial Hypertension 2015;19(4):145-151.

Keywords

telmisartan
angiotensin II receptor blockers
hypertension
guidelines

Authors

Krystyna Widecka

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