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Vol 19, No 4 (2015)
ORIGINAL PAPERS
Published online: 2015-12-31
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Does obstructive sleep apnoea influence BNP concentrations in atrial fibrillation patients?

Anna E. Platek, Alicja Dudzik-Plocica, Karolina Semczuk, Dariusz Gorko, Anna Rys, Marcin Kotkowski, Filip Szymański, Krzysztof J. Filipiak
DOI: 10.5603/AH.2015.0022
·
Arterial Hypertension 2015;19(4):179-186.

open access

Vol 19, No 4 (2015)
ORIGINAL PAPERS
Published online: 2015-12-31

Abstract

Background B-type natriuretic peptide (BNP) is a biomarker commonly used in diagnosing and assessing prognosis in heart failure patients. Its concentration can be elevated in various conditions associated with excessive heart wall stretch including atrial fibrillation and obstructive sleep apnoea (OSA). The aim of the study was to assess if BNP levels in atrial fibrillation patients are associated with the value of apnoea-hypopnea index (AHI).

Material and methods Study population were consecutive patients with atrial fibrillation, who underwent overnight sleep study, and had blood taken for BNP concentration assessment. Subsequently, patients were divided into group according to AHI: Group I (< 5/h), Group II (5–15/h), and Group III (> 15/h).

Results Analysis covered 158 patients (males, 64.6%; mean age, 58.3 ± 9.2 years). 83 (52.5%) patients had AHI < 5/h, Group II consisted of 44 (27.9%), and Group III of 31 (19.6%) patients. Mean BMI and neck circumference rose with AHI value severity. BMI was as follows 28.7 ± 4.3, 30.7 ± 4.7, and 31.8 ± 5.2 kg/m2 (p for trend < 0.01), while neck circumference was 39.2 ± 3.5, 41.5 ± 3.9, and 41.2 ± 3.2 cm, (p for trend = 0.001) for Group I, II, and III respectively. BNP concentration was the lowest in Group I (53.0 ± 57.0 pg/mL), in middle ranges in Group II (69.2 ± 89.9 pg/mL), and the highest in patients with AHI > 15 (104.0 ± 150.8 pg/mL; p for trend = 0.03).

Conclusions Majority of patients with atrial fibrillation have AHI < 5/h and these generally have lower BMI, and neck circumference. Patients who have AHI exceeding ≥ 5/h BNP levels tend to be elevated, and its values rise along with AHI.

Abstract

Background B-type natriuretic peptide (BNP) is a biomarker commonly used in diagnosing and assessing prognosis in heart failure patients. Its concentration can be elevated in various conditions associated with excessive heart wall stretch including atrial fibrillation and obstructive sleep apnoea (OSA). The aim of the study was to assess if BNP levels in atrial fibrillation patients are associated with the value of apnoea-hypopnea index (AHI).

Material and methods Study population were consecutive patients with atrial fibrillation, who underwent overnight sleep study, and had blood taken for BNP concentration assessment. Subsequently, patients were divided into group according to AHI: Group I (< 5/h), Group II (5–15/h), and Group III (> 15/h).

Results Analysis covered 158 patients (males, 64.6%; mean age, 58.3 ± 9.2 years). 83 (52.5%) patients had AHI < 5/h, Group II consisted of 44 (27.9%), and Group III of 31 (19.6%) patients. Mean BMI and neck circumference rose with AHI value severity. BMI was as follows 28.7 ± 4.3, 30.7 ± 4.7, and 31.8 ± 5.2 kg/m2 (p for trend < 0.01), while neck circumference was 39.2 ± 3.5, 41.5 ± 3.9, and 41.2 ± 3.2 cm, (p for trend = 0.001) for Group I, II, and III respectively. BNP concentration was the lowest in Group I (53.0 ± 57.0 pg/mL), in middle ranges in Group II (69.2 ± 89.9 pg/mL), and the highest in patients with AHI > 15 (104.0 ± 150.8 pg/mL; p for trend = 0.03).

Conclusions Majority of patients with atrial fibrillation have AHI < 5/h and these generally have lower BMI, and neck circumference. Patients who have AHI exceeding ≥ 5/h BNP levels tend to be elevated, and its values rise along with AHI.

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Keywords

B-type natriuretic peptide; atrial fibrillation; obstructive sleep apnoea

About this article
Title

Does obstructive sleep apnoea influence BNP concentrations in atrial fibrillation patients?

Journal

Arterial Hypertension

Issue

Vol 19, No 4 (2015)

Pages

179-186

Published online

2015-12-31

DOI

10.5603/AH.2015.0022

Bibliographic record

Arterial Hypertension 2015;19(4):179-186.

Keywords

B-type natriuretic peptide
atrial fibrillation
obstructive sleep apnoea

Authors

Anna E. Platek
Alicja Dudzik-Plocica
Karolina Semczuk
Dariusz Gorko
Anna Rys
Marcin Kotkowski
Filip Szymański
Krzysztof J. Filipiak

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