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Tom 19, Nr 3 (2015)
CASE REPORT
Opublikowany online: 2015-09-29
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The use of fixed dose combinations in the treatment of hypertension — resistant hypertension or patient resistant to treatment?

Rafał Ziemiński, Wojciech Rogala, Aleksandra Waszczuk, Grzegorz Dzida
DOI: 10.5603/AH.2015.0018
·
Arterial Hypertension 2015;19(3):140-144.

dostęp otwarty

Tom 19, Nr 3 (2015)
CASE REPORT
Opublikowany online: 2015-09-29

Streszczenie

Resistant hypertension (RH) is defined as a condition in which blood pressure remains above 140/90 mm Hg despite the use of at least three antihypertensive drugs, correctly combined and in full doses (including a diuretic). In Poland, the percentage of people suffering from RH is estimated at 10–13% relative to the total number of patients with hypertension. On the other hand, in recent years we have seen a significant increase in the importance of combination products both in Europe and in the United States. Several studies have shown that therapy that includes an average of 3 antihypertensive agents (in the form of combination products) having different mechanisms of action, such as blockers of the renin-angiotensin-aldosterone system (RAAS) in combination with a calcium channel blocker (CCB) or a diuretic, provides blood pressure control in the majority of patients, not only through increased efficacy and tolerability of drugs, but also owing to the simplification of the therapeutic regimen, which promotes the compliance with medical recommendations. In this paper we present the case of a patient with resistant hypertension, whose blood pressure normalised only after the use of a combination product.

Streszczenie

Resistant hypertension (RH) is defined as a condition in which blood pressure remains above 140/90 mm Hg despite the use of at least three antihypertensive drugs, correctly combined and in full doses (including a diuretic). In Poland, the percentage of people suffering from RH is estimated at 10–13% relative to the total number of patients with hypertension. On the other hand, in recent years we have seen a significant increase in the importance of combination products both in Europe and in the United States. Several studies have shown that therapy that includes an average of 3 antihypertensive agents (in the form of combination products) having different mechanisms of action, such as blockers of the renin-angiotensin-aldosterone system (RAAS) in combination with a calcium channel blocker (CCB) or a diuretic, provides blood pressure control in the majority of patients, not only through increased efficacy and tolerability of drugs, but also owing to the simplification of the therapeutic regimen, which promotes the compliance with medical recommendations. In this paper we present the case of a patient with resistant hypertension, whose blood pressure normalised only after the use of a combination product.

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Słowa kluczowe

resistant hypertension, combined therapy, calcium channel blocker

Informacje o artykule
Tytuł

The use of fixed dose combinations in the treatment of hypertension — resistant hypertension or patient resistant to treatment?

Czasopismo

Arterial Hypertension

Numer

Tom 19, Nr 3 (2015)

Strony

140-144

Data publikacji on-line

2015-09-29

DOI

10.5603/AH.2015.0018

Rekord bibliograficzny

Arterial Hypertension 2015;19(3):140-144.

Słowa kluczowe

resistant hypertension
combined therapy
calcium channel blocker

Autorzy

Rafał Ziemiński
Wojciech Rogala
Aleksandra Waszczuk
Grzegorz Dzida

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