open access

Vol 19, No 1 (2015)
ORIGINAL PAPERS
Published online: 2015-03-31
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C-reactive protein is not related to ambulatory blood pressure or target organ damage in treated hypertensives

Michał Hoffmann, Katarzyna Polonis, Anna Szyndler, Ewa Świerblewska, Katarzyna Kunicka, Wiesława Kucharska, Robert Nowak, Jacek Wolf, Marzena Chrostowska, Krzysztof Narkiewicz
DOI: 10.5603/AH.2015.0008
·
Arterial Hypertension 2015;19(1):45-49.

open access

Vol 19, No 1 (2015)
ORIGINAL PAPERS
Published online: 2015-03-31

Abstract

Background Publication of the JUPITER trial has renewed the interest in the use of CRP in cardiovascular risk prediction. The aim of the study was to assess the relationship between CRP, ambulatory blood pressure and target organ damage in a cohort of treated hypertensive males without overt cardiovascular disease.
Materials and methods The studied group consisted of 299 male hypertensive patients. Patients were stratified into low (≤ 2 mg/L), intermediate (2–5 mg/L), and high (> 5 mg/L) CRP groups. We measured ambulatory blood pressure, pulse wave velocity, left ventricular function and structure, carotid intima media thickness and ankle-brachial index.
Results Twenty-six percent of the patients had CRP in the range of 2 to 5 mg/L, and 12% had CRP levels exceeding 5 mg/L. Ambulatory blood pressure and heart rate were not different across the three groups. Patients with high CRP had lower HDL cholesterol levels and higher plasma fibrinogen levels. Carotid femoral pulse wave velocity, carotid intima media thickness and ankle-brachial index were not different across the three groups. Echocardiographic data were also not related to the CRP level.
Conclusions
1. Elevated levels of CRP are frequently observed among treated patients with hypertension.
2. CRP elevation is associated with higher fibrinogen and glucose levels, and lower HDL cholesterol independently of obesity and smoking status.
3. Elevated CRP levels are not related to ambulatory blood pressure profile or target organ damage severity.
4. Our findings are consistent with the concept that CRP measurement is of limited value in cardiovascular assessment.

Abstract

Background Publication of the JUPITER trial has renewed the interest in the use of CRP in cardiovascular risk prediction. The aim of the study was to assess the relationship between CRP, ambulatory blood pressure and target organ damage in a cohort of treated hypertensive males without overt cardiovascular disease.
Materials and methods The studied group consisted of 299 male hypertensive patients. Patients were stratified into low (≤ 2 mg/L), intermediate (2–5 mg/L), and high (> 5 mg/L) CRP groups. We measured ambulatory blood pressure, pulse wave velocity, left ventricular function and structure, carotid intima media thickness and ankle-brachial index.
Results Twenty-six percent of the patients had CRP in the range of 2 to 5 mg/L, and 12% had CRP levels exceeding 5 mg/L. Ambulatory blood pressure and heart rate were not different across the three groups. Patients with high CRP had lower HDL cholesterol levels and higher plasma fibrinogen levels. Carotid femoral pulse wave velocity, carotid intima media thickness and ankle-brachial index were not different across the three groups. Echocardiographic data were also not related to the CRP level.
Conclusions
1. Elevated levels of CRP are frequently observed among treated patients with hypertension.
2. CRP elevation is associated with higher fibrinogen and glucose levels, and lower HDL cholesterol independently of obesity and smoking status.
3. Elevated CRP levels are not related to ambulatory blood pressure profile or target organ damage severity.
4. Our findings are consistent with the concept that CRP measurement is of limited value in cardiovascular assessment.
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Keywords

ambulatory blood pressure, arterial stiffness, C-reactive protein, hypertension, inflammation, left ventricular hypertrophy, pulse wave velocity, target organ damage

About this article
Title

C-reactive protein is not related to ambulatory blood pressure or target organ damage in treated hypertensives

Journal

Arterial Hypertension

Issue

Vol 19, No 1 (2015)

Pages

45-49

Published online

2015-03-31

DOI

10.5603/AH.2015.0008

Bibliographic record

Arterial Hypertension 2015;19(1):45-49.

Keywords

ambulatory blood pressure
arterial stiffness
C-reactive protein
hypertension
inflammation
left ventricular hypertrophy
pulse wave velocity
target organ damage

Authors

Michał Hoffmann
Katarzyna Polonis
Anna Szyndler
Ewa Świerblewska
Katarzyna Kunicka
Wiesława Kucharska
Robert Nowak
Jacek Wolf
Marzena Chrostowska
Krzysztof Narkiewicz

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