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Genetic alterations in B-acute lymphoblastic leukemia
Affiliations- Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
- Department of Anatomical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
open access
Abstract
Considerable advances have been made in treatment of acute lymphoblastic leukemia (ALL) with an overall survival rate of 85% in children, and with a great improvement in adults. Despite this improvements and the accessibility of hematopoietic stem cell transplantation, relapsed ALL remains a leading cause of childhood mortality emphasizing the need of new approaches on therapy. Understanding of the pathobiology and genetic alteration of ALL has been enhanced by developing molecular technologies including microarray analysis and genome sequencing. These studies have helped identifying mutations in key signaling pathways and revolutionized the treatment of ALL by drugs which specifically target the genetic defects of leukemia cells, such as tyrosine kinase inhibitors. In this paper, we review the clinically important Genetic Alterations in ALL.
Abstract
Considerable advances have been made in treatment of acute lymphoblastic leukemia (ALL) with an overall survival rate of 85% in children, and with a great improvement in adults. Despite this improvements and the accessibility of hematopoietic stem cell transplantation, relapsed ALL remains a leading cause of childhood mortality emphasizing the need of new approaches on therapy. Understanding of the pathobiology and genetic alteration of ALL has been enhanced by developing molecular technologies including microarray analysis and genome sequencing. These studies have helped identifying mutations in key signaling pathways and revolutionized the treatment of ALL by drugs which specifically target the genetic defects of leukemia cells, such as tyrosine kinase inhibitors. In this paper, we review the clinically important Genetic Alterations in ALL.
Keywords
Genetic alterations; Leukemia; Signal transduction; Review
About this articleTitle
Genetic alterations in B-acute lymphoblastic leukemia
Journal
Issue
Pages
10-17
Published online
2017-01-01
DOI
10.1016/j.achaem.2016.11.002
Bibliographic record
Acta Haematol Pol 2017;48(1):10-17.
Keywords
Genetic alterations
Leukemia
Signal transduction
Review
Authors
Seyedeh Momeneh Mohammadi
Daryosh Mohammad Nejad
Hojjatollah Nozad Charoudeh