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The evaluation of the healing of fresh arterial allografts in infected environments
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Abstract
Material and methods. The arterial allograft was stored with the application of cold ischemia method in a preservation solution at 4°C. Duplex-Doppler Ultrasound and scintigraphy with the use of technetiumlabelled leukocytes were used in the diagnostic evaluation of infection and of the healing process of the homograft. During the follow up period, patients in whom fresh homografts were used were divided into two groups: group I received immunosuppressive regimen after surgery (24 patients) and group II received no immunosuppression (26 patients).
Results. In group I, no complications due to the homograft's wall degradation (e.g. graft rupture) were noticed. In group II, complications related to the impairment of the allograft wall were observed: graft rupture, true graft aneurysm and homograft thrombosis. In all groups the regression of infection after in-situ replacement of the synthetic prosthesis with the homograft was monitored with scintigraphy examination.
Conclusion. The use of arterial homograft with the application of cold ischemia method and immunosuppression in the therapy of prosthetic graft infection is a proper treatment method.
Abstract
Material and methods. The arterial allograft was stored with the application of cold ischemia method in a preservation solution at 4°C. Duplex-Doppler Ultrasound and scintigraphy with the use of technetiumlabelled leukocytes were used in the diagnostic evaluation of infection and of the healing process of the homograft. During the follow up period, patients in whom fresh homografts were used were divided into two groups: group I received immunosuppressive regimen after surgery (24 patients) and group II received no immunosuppression (26 patients).
Results. In group I, no complications due to the homograft's wall degradation (e.g. graft rupture) were noticed. In group II, complications related to the impairment of the allograft wall were observed: graft rupture, true graft aneurysm and homograft thrombosis. In all groups the regression of infection after in-situ replacement of the synthetic prosthesis with the homograft was monitored with scintigraphy examination.
Conclusion. The use of arterial homograft with the application of cold ischemia method and immunosuppression in the therapy of prosthetic graft infection is a proper treatment method.
Keywords
arterial allograft; immunosuppression; prosthetic graft infections; scintigraphy with use of technetium-labelled leukocytes
About this articleTitle
The evaluation of the healing of fresh arterial allografts in infected environments
Journal
Issue
Article type
Research paper
Pages
16-22
Published online
2006-03-27
Page views
663
Article views/downloads
1576
DOI
10.5603/aa.9878
Bibliographic record
Acta Angiologica 2006;12(1):16-22.
Keywords
arterial allograft
immunosuppression
prosthetic graft infections
scintigraphy with use of technetium-labelled leukocytes
Authors
Artur Pupka
Jan Skóra
Piotr Barć
Andrzej T. Dorobisz
Dariusz Janczak
Stanisław Pawłowski