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Vol 3, No 2 (2001)
Prace oryginalne
Published online: 2002-11-25
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The role of lipoprotein(a) in ischemic stroke

Małgorzata Krześniak-Bohdan, Małgorzata Wróblewska, Zyta Banecka-Majkutewicz, Walenty M. Nyka, Hanna Wójcik-Drączkowska, Małgorzata Świerkocka-Miastkowska
Udar Mózgu. Problemy Interdyscyplinarne 2001;3(2):43-46.

open access

Vol 3, No 2 (2001)
Prace oryginalne
Published online: 2002-11-25

Abstract

Lipoprotein(a) (Lp(a)) is a low-density lipoprotein (LDL) - like substance whose protein component is apolipoprotein(a) linked to apolipoprotein B-100. Lp(a) play an important role in thrombogenesis and atherosclerosis and is considered to be an independent, genetically determined, risk factor for atherosclerosis. The correlation of the serum level of lipoprotein(a) with an ischaemic brain infarction has not been fully established.
The aim of this study was to determine the occurence of increased levels of Lp(a) in patients with ischaemic stroke and to establish the correlation between serum Lp(a) concentration and various conventional risk factors of ischaemic stroke.
Materials and methods. We evaluated a group of 159 patients 3 months after ischaemic stroke (104 males and 55 females), aged 40–89 years (mean age 66.4) and 137 control subjects with no history of stroke.
Results. A high Lp(a) level above 30 mg/dl was found in 71 (44.65%) patients with ischaemic stroke and in 36 (26.2%) controls. The mean level of Lp(a) was higher in patients with history of ischaemic stroke than in control group (46.21 mg/dL and 27.65 mg/dL respectively). Some risk factors of stroke were analyzed in patients with high Lp(a) (Lp(a)+) and with normal level of Lp(a) (Lp(a)–). Hypertension, coronary heart disease, atrial fibrillation, diabetes mellitus, hyperlipidemia appeared with similar frequency in both groups. Changes in carotid arteries occured more frequently in Lp(a)+ group, but it was not statistically significant. There were more patients aged 40–50 years in Lp(a)+ than in Lp(a)– group (12 (16.9%) and 6 (6.82%) respectively), but this difference was also not statistically significant.
Conclusions. 1. We observed higher Lp(a) level in patients with other risk factors and with history of ischaemic stroke in comparison with the control group; 2. There were no statistically significant correlations between high serum level of lipoprotein(a) and age of patients or other conventional risk factors; 3. Because of complex etiology of stroke more clinical investigation is needed to establish the association between different lipoprotein subtypes in atherothrombotic patients, (especially those with ischaemic cerebral infarction).

Abstract

Lipoprotein(a) (Lp(a)) is a low-density lipoprotein (LDL) - like substance whose protein component is apolipoprotein(a) linked to apolipoprotein B-100. Lp(a) play an important role in thrombogenesis and atherosclerosis and is considered to be an independent, genetically determined, risk factor for atherosclerosis. The correlation of the serum level of lipoprotein(a) with an ischaemic brain infarction has not been fully established.
The aim of this study was to determine the occurence of increased levels of Lp(a) in patients with ischaemic stroke and to establish the correlation between serum Lp(a) concentration and various conventional risk factors of ischaemic stroke.
Materials and methods. We evaluated a group of 159 patients 3 months after ischaemic stroke (104 males and 55 females), aged 40–89 years (mean age 66.4) and 137 control subjects with no history of stroke.
Results. A high Lp(a) level above 30 mg/dl was found in 71 (44.65%) patients with ischaemic stroke and in 36 (26.2%) controls. The mean level of Lp(a) was higher in patients with history of ischaemic stroke than in control group (46.21 mg/dL and 27.65 mg/dL respectively). Some risk factors of stroke were analyzed in patients with high Lp(a) (Lp(a)+) and with normal level of Lp(a) (Lp(a)–). Hypertension, coronary heart disease, atrial fibrillation, diabetes mellitus, hyperlipidemia appeared with similar frequency in both groups. Changes in carotid arteries occured more frequently in Lp(a)+ group, but it was not statistically significant. There were more patients aged 40–50 years in Lp(a)+ than in Lp(a)– group (12 (16.9%) and 6 (6.82%) respectively), but this difference was also not statistically significant.
Conclusions. 1. We observed higher Lp(a) level in patients with other risk factors and with history of ischaemic stroke in comparison with the control group; 2. There were no statistically significant correlations between high serum level of lipoprotein(a) and age of patients or other conventional risk factors; 3. Because of complex etiology of stroke more clinical investigation is needed to establish the association between different lipoprotein subtypes in atherothrombotic patients, (especially those with ischaemic cerebral infarction).
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Keywords

lipoprotein(a); ischemic stroke; risk factors

About this article
Title

The role of lipoprotein(a) in ischemic stroke

Journal

Interdisciplinary Problems of Stroke

Issue

Vol 3, No 2 (2001)

Pages

43-46

Published online

2002-11-25

Bibliographic record

Udar Mózgu. Problemy Interdyscyplinarne 2001;3(2):43-46.

Keywords

lipoprotein(a)
ischemic stroke
risk factors

Authors

Małgorzata Krześniak-Bohdan
Małgorzata Wróblewska
Zyta Banecka-Majkutewicz
Walenty M. Nyka
Hanna Wójcik-Drączkowska
Małgorzata Świerkocka-Miastkowska

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