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Vol 4, No 2 (2002)
Prace oryginalne
Published online: 2003-03-11
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Plasma fibrinogen and dynamism of acute phase of ischemic stroke

Anna Bajer-Czajkowska, Przemysław Nowacki, Danuta Nocoń, Jarosław Podbielski
Udar Mózgu. Problemy Interdyscyplinarne 2002;4(2):47-51.

open access

Vol 4, No 2 (2002)
Prace oryginalne
Published online: 2003-03-11

Abstract

Background. Elevated plasma fibrinogen level is associated with coronary heart disease and stroke. In spite of a large number of studies it is still uncertain whether increased level of plasma fibrinogen is one of the causes of stroke or whether it is only a high-risk marker. We evaluated the association between plasma fibrinogen level and the dynamism of acute phase of ischemic stroke and therefore, if it might be a prognostic factor for fatal dynamism of acute phase of stroke.
Material and methods. The prospective studies were done on 248 patients with ischemic stroke. Plasma fibrinogen was measured by means of Clauss's method within first 48 hours of hospitalisation. Depending on fibrinogen levels, patients were divided in three groups, taking also into consideration, whether there was a complete (CS) or progressive (PS) stroke, reversible ischemic neurological deficit (RIND) or transient ischemic attack (TIA).
Results. Patients with plasma fibrinogen level between 300–400 mg/dL were the greatest group among all investigated individuals. Moreover, it turned out, that within the group of patients with fibrinogen level exceeding 400 mg/dL, CS percentage appeared to be significantly higher than RIND and TIA. Progressive strokes were also significantly more frequent in patients with fibrinogen level between 300–400 mg/dL.
Conclusions. The elevated plasma fibrinogen level facilitates the unfavourable clinical course of acute phase of ischemic stroke, especially of PS type, therefore it should be treated as a pathogenic factor, resulting in ischemic lesion in the brain, and not only as a high-risk marker of stroke. The individuals, in whom the plasma fibrinogen level appears within the upper range of values considered as a norm (300–400 mg/dL), should be classified into the group of higher risk of ischemic stroke.

Abstract

Background. Elevated plasma fibrinogen level is associated with coronary heart disease and stroke. In spite of a large number of studies it is still uncertain whether increased level of plasma fibrinogen is one of the causes of stroke or whether it is only a high-risk marker. We evaluated the association between plasma fibrinogen level and the dynamism of acute phase of ischemic stroke and therefore, if it might be a prognostic factor for fatal dynamism of acute phase of stroke.
Material and methods. The prospective studies were done on 248 patients with ischemic stroke. Plasma fibrinogen was measured by means of Clauss's method within first 48 hours of hospitalisation. Depending on fibrinogen levels, patients were divided in three groups, taking also into consideration, whether there was a complete (CS) or progressive (PS) stroke, reversible ischemic neurological deficit (RIND) or transient ischemic attack (TIA).
Results. Patients with plasma fibrinogen level between 300–400 mg/dL were the greatest group among all investigated individuals. Moreover, it turned out, that within the group of patients with fibrinogen level exceeding 400 mg/dL, CS percentage appeared to be significantly higher than RIND and TIA. Progressive strokes were also significantly more frequent in patients with fibrinogen level between 300–400 mg/dL.
Conclusions. The elevated plasma fibrinogen level facilitates the unfavourable clinical course of acute phase of ischemic stroke, especially of PS type, therefore it should be treated as a pathogenic factor, resulting in ischemic lesion in the brain, and not only as a high-risk marker of stroke. The individuals, in whom the plasma fibrinogen level appears within the upper range of values considered as a norm (300–400 mg/dL), should be classified into the group of higher risk of ischemic stroke.
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Keywords

ischemic stroke; acute phase; fibrinogen; dynamism; prognosis

About this article
Title

Plasma fibrinogen and dynamism of acute phase of ischemic stroke

Journal

Interdisciplinary Problems of Stroke

Issue

Vol 4, No 2 (2002)

Pages

47-51

Published online

2003-03-11

Bibliographic record

Udar Mózgu. Problemy Interdyscyplinarne 2002;4(2):47-51.

Keywords

ischemic stroke
acute phase
fibrinogen
dynamism
prognosis

Authors

Anna Bajer-Czajkowska
Przemysław Nowacki
Danuta Nocoń
Jarosław Podbielski

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