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Vol 5, No 2 (2003)
Prace kazuistyczne
Published online: 2003-08-04
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Twice repeated ischemic brain infarct in patient with primary antiphospholipid syndrome and S-protein deficiency

Zofia Kazibutowska, Ewa Motta, Anna Gołba, Magdalena Stelmach-Wawrzyczek, Barbara Rogoż
Udar Mózgu. Problemy Interdyscyplinarne 2003;5(2):31-36.

open access

Vol 5, No 2 (2003)
Prace kazuistyczne
Published online: 2003-08-04

Abstract

There is no uniform conception dealing with the role that hereditary deficit of natural coagulation inhibitors (to which belong S-protein) plays in cases of brain ischemic infarcts in young persons. We present the case of man (at present 50-years-old) with history of thrombotic disease in family (mother and father), who experienced triple inflammation of pelvic limbs veins and in his 46th and 47th years of life experienced in succeeding ischemic strokes of the left and next of the right temporal lobe. Moreover since his 24th year he had transitory episodes of sight disturbances. Examinations carried out (IgG and IgM class anticardiolipin antibodies) permitted to diagnose the primary antiphospholipid syndrome. Analysis of coagulation showed decreased serum concentration (50% and 45%) likely of hereditary nature because acquired causes of diminished serum S concentration of this protein were excluded.
It seems, that S-protein deficiency in our patient was next to antiphospholipid syndrome and additional factor favouring thrombosis.

Abstract

There is no uniform conception dealing with the role that hereditary deficit of natural coagulation inhibitors (to which belong S-protein) plays in cases of brain ischemic infarcts in young persons. We present the case of man (at present 50-years-old) with history of thrombotic disease in family (mother and father), who experienced triple inflammation of pelvic limbs veins and in his 46th and 47th years of life experienced in succeeding ischemic strokes of the left and next of the right temporal lobe. Moreover since his 24th year he had transitory episodes of sight disturbances. Examinations carried out (IgG and IgM class anticardiolipin antibodies) permitted to diagnose the primary antiphospholipid syndrome. Analysis of coagulation showed decreased serum concentration (50% and 45%) likely of hereditary nature because acquired causes of diminished serum S concentration of this protein were excluded.
It seems, that S-protein deficiency in our patient was next to antiphospholipid syndrome and additional factor favouring thrombosis.
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Keywords

antiphospholipid syndrome; protein S; ischemic stroke

About this article
Title

Twice repeated ischemic brain infarct in patient with primary antiphospholipid syndrome and S-protein deficiency

Journal

Interdisciplinary Problems of Stroke

Issue

Vol 5, No 2 (2003)

Pages

31-36

Published online

2003-08-04

Bibliographic record

Udar Mózgu. Problemy Interdyscyplinarne 2003;5(2):31-36.

Keywords

antiphospholipid syndrome
protein S
ischemic stroke

Authors

Zofia Kazibutowska
Ewa Motta
Anna Gołba
Magdalena Stelmach-Wawrzyczek
Barbara Rogoż

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