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open access

Vol 6, No 2 (2004)
Prace oryginalne
Published online: 2004-06-23
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Risk factors of ischemic stroke in children II. Lipid metabolism abnormalities in etiopathogenesis of ischemic stroke in children

Ilona Kopyta, Elżbieta Marszał
Udar Mózgu. Problemy Interdyscyplinarne 2004;6(2):57-64.

open access

Vol 6, No 2 (2004)
Prace oryginalne
Published online: 2004-06-23

Abstract

Background. Ischemic stroke is rather rare condition in children. It occurs with the frequency of 0.63/100 000/year. After that the consequences of stroke, like motor disturbances, speach problems, developmental delay and epileptic seizures, are significant for child’e future life.
This is why the attempt to establish of risk factors of stroke and its potential reccurence in every patient is so important. In spite of „classical” risk factors, like inherited and aquired heart diseases or infections also biochemical disturbances, e.g. lipid metabolism and hiperlipoproteinemia (a), are concidered. The aim of the study was evaluation of lipid metabolism parameters and concentration of lp(a) in children who underwent ischemic stroke and comparison of the data with the group of healthy children.
Material and methods. The examination was conducted in 38 children (16 girls and 22 boys). The personal medical history profile concerning the actual illness and directed towards the occurence of cerebrovascular diseases in patient’s family was created for each patient. Physical and neurological examination, and neuroimaging were performed in each case. Moreover the examination of blood serum concentration of: total cholesterol and it’s fractions, triglicerides and lp(a) was performed. The control group consisted of 38 healthy children of similiar age.
Results. Statistically significant differences between both examined and control groups has been proved in the concentration of total cholesterol and it’s fractions, and lp(a).
Conclusions. It is necessary to perform the analysis of serum lipids in each pediatric patient after an acute ischemic event of CNS even if "traditional" risk factors of stroke were found.

Abstract

Background. Ischemic stroke is rather rare condition in children. It occurs with the frequency of 0.63/100 000/year. After that the consequences of stroke, like motor disturbances, speach problems, developmental delay and epileptic seizures, are significant for child’e future life.
This is why the attempt to establish of risk factors of stroke and its potential reccurence in every patient is so important. In spite of „classical” risk factors, like inherited and aquired heart diseases or infections also biochemical disturbances, e.g. lipid metabolism and hiperlipoproteinemia (a), are concidered. The aim of the study was evaluation of lipid metabolism parameters and concentration of lp(a) in children who underwent ischemic stroke and comparison of the data with the group of healthy children.
Material and methods. The examination was conducted in 38 children (16 girls and 22 boys). The personal medical history profile concerning the actual illness and directed towards the occurence of cerebrovascular diseases in patient’s family was created for each patient. Physical and neurological examination, and neuroimaging were performed in each case. Moreover the examination of blood serum concentration of: total cholesterol and it’s fractions, triglicerides and lp(a) was performed. The control group consisted of 38 healthy children of similiar age.
Results. Statistically significant differences between both examined and control groups has been proved in the concentration of total cholesterol and it’s fractions, and lp(a).
Conclusions. It is necessary to perform the analysis of serum lipids in each pediatric patient after an acute ischemic event of CNS even if "traditional" risk factors of stroke were found.
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Keywords

ischemic stroke; children; lipid metabolism abnormalities; hyperlipoproteinemia (a)

About this article
Title

Risk factors of ischemic stroke in children II. Lipid metabolism abnormalities in etiopathogenesis of ischemic stroke in children

Journal

Interdisciplinary Problems of Stroke

Issue

Vol 6, No 2 (2004)

Pages

57-64

Published online

2004-06-23

Bibliographic record

Udar Mózgu. Problemy Interdyscyplinarne 2004;6(2):57-64.

Keywords

ischemic stroke
children
lipid metabolism abnormalities
hyperlipoproteinemia (a)

Authors

Ilona Kopyta
Elżbieta Marszał

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