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open access

Vol 7, No 2 (2005)
Prace poglądowe
Published online: 2005-09-12
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Hyperhomocysteinemia - important risk factor for ischemic stroke

Zyta Banecka-Majkutewicz, Dariusz Gąsecki, Joanna Jakóbkiewicz-Banecka, Bogdan Banecki, Grzegorz Węgrzyn, Walenty M. Nyka
Udar Mózgu. Problemy Interdyscyplinarne 2005;7(2):61-65.

open access

Vol 7, No 2 (2005)
Prace poglądowe
Published online: 2005-09-12

Abstract

Hyperhomocysteinemia is emerging as possible risk factor for cardiovascular disease, including cerebral stroke. Stroke is one of the leading causes of mortality and disability in Poland. The etiology of stroke is often unknown; it has been estimated that etiology and pathophysiology in more that 40% of strokes remains unexplained. Hyperhomocysteinemia is considered a modifiable risk factor for stroke, possibly because of atherogenic and prothrombotic mechanism. Both, genetics and environmental (e.g. dietary intake of folic acid and B vitamins) factors affects homocysteine level. One of the most common genetics defects of homocysteine metabolism is a mutation in the enzyme methylenetetrahydrofolate reductase (MTHFR), metionine syntase (MS) and cystationine beta syntase (CBS). Identification of the role of hyperhomocysteinemia as the modifiable risk factor for stroke may lead to more effective prevention of stroke through dietary and pharmacological modification of homocysteine level.

Abstract

Hyperhomocysteinemia is emerging as possible risk factor for cardiovascular disease, including cerebral stroke. Stroke is one of the leading causes of mortality and disability in Poland. The etiology of stroke is often unknown; it has been estimated that etiology and pathophysiology in more that 40% of strokes remains unexplained. Hyperhomocysteinemia is considered a modifiable risk factor for stroke, possibly because of atherogenic and prothrombotic mechanism. Both, genetics and environmental (e.g. dietary intake of folic acid and B vitamins) factors affects homocysteine level. One of the most common genetics defects of homocysteine metabolism is a mutation in the enzyme methylenetetrahydrofolate reductase (MTHFR), metionine syntase (MS) and cystationine beta syntase (CBS). Identification of the role of hyperhomocysteinemia as the modifiable risk factor for stroke may lead to more effective prevention of stroke through dietary and pharmacological modification of homocysteine level.
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Keywords

homocysteine; genetics; ischemic stroke; risk factors

About this article
Title

Hyperhomocysteinemia - important risk factor for ischemic stroke

Journal

Interdisciplinary Problems of Stroke

Issue

Vol 7, No 2 (2005)

Pages

61-65

Published online

2005-09-12

Bibliographic record

Udar Mózgu. Problemy Interdyscyplinarne 2005;7(2):61-65.

Keywords

homocysteine
genetics
ischemic stroke
risk factors

Authors

Zyta Banecka-Majkutewicz
Dariusz Gąsecki
Joanna Jakóbkiewicz-Banecka
Bogdan Banecki
Grzegorz Węgrzyn
Walenty M. Nyka

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