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Vol 8, No 1 (2006)
Prace poglądowe
Published online: 2006-01-23
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Hematological aspects of stroke

Eugenia Częstochowska, Krzysztof Sworczak
Udar Mózgu. Problemy Interdyscyplinarne 2006;8(1):28-33.

open access

Vol 8, No 1 (2006)
Prace poglądowe
Published online: 2006-01-23

Abstract

The etiology of stroke still remains uncertain in a large number of cases. Haematological disorders in some percentage may be associated with ischaemic as well as haemorrhagic stroke, transient ischaemic attack or cerebral venous thrombosis. These includes cellular disorders such as polycythaemia rubra vera, essential thrombocythaemia, thrombocytopenia, leucaemia and other disorders. It is difficult to determine the importance of coagulation disturbances in the pathogenesis of stroke since large case control studies have not yet been performed. Recently particular interest has centred on various hereditary deficiencies of natural anticoagulants in the pathogenesis of stroke. Among them defeciences of antitrombin, protein C and S, activated protein C resistance, the mutations of factor V1691 GA (factor V Leiden mutation) and prothrombin 20210 GA as well as congenital fibrinolytic system disturbances have been linked with stroke in case reports. Disseminated intravascular coagulation, antiphospholipid syndrome, represents acquired coagulation disorders linked with different types of stroke.
Increased risk was assessed in women taking oral contraceptives or rarely hormonal replacement therapy. The number and kind of hematological factors playing an ethiological role in stroke is still uncertain and warrants further investigations.

Abstract

The etiology of stroke still remains uncertain in a large number of cases. Haematological disorders in some percentage may be associated with ischaemic as well as haemorrhagic stroke, transient ischaemic attack or cerebral venous thrombosis. These includes cellular disorders such as polycythaemia rubra vera, essential thrombocythaemia, thrombocytopenia, leucaemia and other disorders. It is difficult to determine the importance of coagulation disturbances in the pathogenesis of stroke since large case control studies have not yet been performed. Recently particular interest has centred on various hereditary deficiencies of natural anticoagulants in the pathogenesis of stroke. Among them defeciences of antitrombin, protein C and S, activated protein C resistance, the mutations of factor V1691 GA (factor V Leiden mutation) and prothrombin 20210 GA as well as congenital fibrinolytic system disturbances have been linked with stroke in case reports. Disseminated intravascular coagulation, antiphospholipid syndrome, represents acquired coagulation disorders linked with different types of stroke.
Increased risk was assessed in women taking oral contraceptives or rarely hormonal replacement therapy. The number and kind of hematological factors playing an ethiological role in stroke is still uncertain and warrants further investigations.
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Keywords

stroke; cellular hematological disturbances; coagulation abnormalities; thrombophilia; antiphospholipid syndrome; contraception

About this article
Title

Hematological aspects of stroke

Journal

Interdisciplinary Problems of Stroke

Issue

Vol 8, No 1 (2006)

Pages

28-33

Published online

2006-01-23

Bibliographic record

Udar Mózgu. Problemy Interdyscyplinarne 2006;8(1):28-33.

Keywords

stroke
cellular hematological disturbances
coagulation abnormalities
thrombophilia
antiphospholipid syndrome
contraception

Authors

Eugenia Częstochowska
Krzysztof Sworczak

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