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Vol 8, No 1 (2006)
Prace oryginalne
Published online: 2006-01-23
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Risk factors for hemorrhagic transformation in ischemic stroke

Maria Ejma, Konstanty Gurański, Ryszard Podemski, Mieszko Zagrajek, Krzysztof Kowalewski
Udar Mózgu. Problemy Interdyscyplinarne 2006;8(1):10-15.

open access

Vol 8, No 1 (2006)
Prace oryginalne
Published online: 2006-01-23

Abstract

Introduction. Risk factors for hemorrhagic transformation in ischemic stroke were analyzed in the patients who were treated in the Neurology Department in Wroclaw between 2002-2005.
Material and methods. 125 patients (46 women and 79 men), age range 21 to 84 years (mean 57 years) with supratentorial ischemic stroke were included. CT scans were performed on the first (CT1) and fifth (CT2) day after symptoms onset. Based on CT scan results, patients were classified into 2 groups: I - with hemorrhagic transformation (n = 99) and II - without hemorrhagic transformation (n = 26). Potential risk factors for hemorrhagic transformation were evaluated, such as hypertension, diabetes, atrial fibrillation, internal cerebral artery occlusion, serum cholesterol level, stroke mechanism (embolic or thrombotic), severity of the neurological deficit (assessed by means of the Orgogozo Scale).
Results. 113 patients (90.4%) had infarction involving the middle cerebral artery (MCA) territory and in 12 (9.6%) patient infarction was located in posterior cerebral artery (PCA) territory. Hemorrhagic transformation occurred in 26 patients (21%): in 23 patients with infarction of MCA territory and in 3 with PCA territory. Embolic stroke, severe neurological deficit, early major ischemic changes on CT scan were associated with increased risk of hemorrhagic transformation. Internal cerebral artery occlusion on Doppler examination was detected more frequently in patients without hemorrhage. No association between hypertension, diabetes, atrial fibrillation, serum cholesterol level and hemorrhagic transformation was found.
Conclusions. Embolic stroke, severe neurological deficit, early major ischemic changes on CT scan could be predictive of hemorrhagic transformation in stroke.

Abstract

Introduction. Risk factors for hemorrhagic transformation in ischemic stroke were analyzed in the patients who were treated in the Neurology Department in Wroclaw between 2002-2005.
Material and methods. 125 patients (46 women and 79 men), age range 21 to 84 years (mean 57 years) with supratentorial ischemic stroke were included. CT scans were performed on the first (CT1) and fifth (CT2) day after symptoms onset. Based on CT scan results, patients were classified into 2 groups: I - with hemorrhagic transformation (n = 99) and II - without hemorrhagic transformation (n = 26). Potential risk factors for hemorrhagic transformation were evaluated, such as hypertension, diabetes, atrial fibrillation, internal cerebral artery occlusion, serum cholesterol level, stroke mechanism (embolic or thrombotic), severity of the neurological deficit (assessed by means of the Orgogozo Scale).
Results. 113 patients (90.4%) had infarction involving the middle cerebral artery (MCA) territory and in 12 (9.6%) patient infarction was located in posterior cerebral artery (PCA) territory. Hemorrhagic transformation occurred in 26 patients (21%): in 23 patients with infarction of MCA territory and in 3 with PCA territory. Embolic stroke, severe neurological deficit, early major ischemic changes on CT scan were associated with increased risk of hemorrhagic transformation. Internal cerebral artery occlusion on Doppler examination was detected more frequently in patients without hemorrhage. No association between hypertension, diabetes, atrial fibrillation, serum cholesterol level and hemorrhagic transformation was found.
Conclusions. Embolic stroke, severe neurological deficit, early major ischemic changes on CT scan could be predictive of hemorrhagic transformation in stroke.
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Keywords

ischemic stroke; hemorrhagic transformation; risk factors

About this article
Title

Risk factors for hemorrhagic transformation in ischemic stroke

Journal

Interdisciplinary Problems of Stroke

Issue

Vol 8, No 1 (2006)

Pages

10-15

Published online

2006-01-23

Bibliographic record

Udar Mózgu. Problemy Interdyscyplinarne 2006;8(1):10-15.

Keywords

ischemic stroke
hemorrhagic transformation
risk factors

Authors

Maria Ejma
Konstanty Gurański
Ryszard Podemski
Mieszko Zagrajek
Krzysztof Kowalewski

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