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Vol 9, No 1 (2007)
Prace oryginalne
Published online: 2007-03-14
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Changes of cerebral blood flow in stroke patients depending on frequency of mannitol drip

Magdalena Nowaczewska, Barbara Książkiewicz
Udar Mózgu. Problemy Interdyscyplinarne 2007;9(1):14-23.

open access

Vol 9, No 1 (2007)
Prace oryginalne
Published online: 2007-03-14

Abstract


Background. The most popular pharmacological therapy of intracranial hypertension is osmotherapy using mannitol. Mannitol dose, frequency of drips and time of treatment causes a lot of discussion. Because of age and coexisting diseases stroke patients are very prone of treatment. The aim of this study was to assess the influence of mannitol on cerebral blood floow depending on frequency of mannitol drip.
Material and methods. 30 patients with intracranial hypertension as a complication of supratentorial stroke were treated with 20% mannitol. The patients were divided to 2 groups, depending on mannitol drip frequency: every 6 (16 patients) and every 8 hours (14 patients). Before mannitol drip neurological examination with the assessment in GSC scale was performed. This procedure was repeated 60 minutes after mannitol drip. After neurological examination, before and 30 and 60 min after mannitol drip TCD was performed including mesutement of mean velocity (BFV) and pulsatility index (PI) in both MCA.
Results. In the group of patients treating with mannitol drip every 6 hours, before every drip, in MCA in healthy side BFV was statistically higher and PI was lower then in the group treating with mannitol every 8 hours. 30 minutes after mannitol drip BFV increased and PI decreased in both MCA: changes were greater in the group of patients treating with mannitol more frequently. In both groups, 60 min. after mannitol drip, GCS scoring increased, more in the group treating with mannitol more frequently.

Abstract


Background. The most popular pharmacological therapy of intracranial hypertension is osmotherapy using mannitol. Mannitol dose, frequency of drips and time of treatment causes a lot of discussion. Because of age and coexisting diseases stroke patients are very prone of treatment. The aim of this study was to assess the influence of mannitol on cerebral blood floow depending on frequency of mannitol drip.
Material and methods. 30 patients with intracranial hypertension as a complication of supratentorial stroke were treated with 20% mannitol. The patients were divided to 2 groups, depending on mannitol drip frequency: every 6 (16 patients) and every 8 hours (14 patients). Before mannitol drip neurological examination with the assessment in GSC scale was performed. This procedure was repeated 60 minutes after mannitol drip. After neurological examination, before and 30 and 60 min after mannitol drip TCD was performed including mesutement of mean velocity (BFV) and pulsatility index (PI) in both MCA.
Results. In the group of patients treating with mannitol drip every 6 hours, before every drip, in MCA in healthy side BFV was statistically higher and PI was lower then in the group treating with mannitol every 8 hours. 30 minutes after mannitol drip BFV increased and PI decreased in both MCA: changes were greater in the group of patients treating with mannitol more frequently. In both groups, 60 min. after mannitol drip, GCS scoring increased, more in the group treating with mannitol more frequently.
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Keywords

stroke; osmotherapy; transcranial Doppler

About this article
Title

Changes of cerebral blood flow in stroke patients depending on frequency of mannitol drip

Journal

Interdisciplinary Problems of Stroke

Issue

Vol 9, No 1 (2007)

Pages

14-23

Published online

2007-03-14

Bibliographic record

Udar Mózgu. Problemy Interdyscyplinarne 2007;9(1):14-23.

Keywords

stroke
osmotherapy
transcranial Doppler

Authors

Magdalena Nowaczewska
Barbara Książkiewicz

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