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open access

Vol 9, No 1 (2007)
Prace oryginalne
Published online: 2007-03-14
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Polymorphism of the angiotensin-converting enzyme encoding gene in stroke patients

Barbara Gaweł, Andrzej Wajgt, Sabina Gałka, Joanna Głogowska-Ligus, Urszula Mazurek, Joanna Pilsch-Kowalczyk
Udar Mózgu. Problemy Interdyscyplinarne 2007;9(1):8-13.

open access

Vol 9, No 1 (2007)
Prace oryginalne
Published online: 2007-03-14

Abstract


Background. The objective of the study was to determine and compare the frequency of occurrence of polymorphic insertion/deletion (I/D) variants of the angiotensin-converting encoding gene in patients with ischemic and haemorrhagic stroke, with or without arterial hypertension.
Material and methods. DNA from peripheral blood of 87 patients with recent cerebral stroke, aged 30 to 65, was analysed. The cerebral stroke was diagnosed on the basis of focal neurological symptoms persisting for more than 24 hours, confirmed by CT or NRM imaging. The control group consisted of 45 volunteers aged 30 to 65. ACE genotype was examined using PCR.
Results. Investigation of insertion/deletion polymorphism of angiotensin-converting encoding gene gave the following results: in the ischemic stroke group: II -18.2%, ID - 60.6%, DD - 21.2%, in haemorrhagic stroke: II - 23.8%, ID - 42.9%, DD- 33.3%, in the control group: II - 24.5%, ID - 42.2%, DD - 33.3%.
Conclusions. Our results, like the conclusions of most researchers, point to absence of relationship between the type of ACE polymorphism and the prevalence of cerebral stroke. This polymorphism plays no major role in the pathogenesis of cerebral stroke.

Abstract


Background. The objective of the study was to determine and compare the frequency of occurrence of polymorphic insertion/deletion (I/D) variants of the angiotensin-converting encoding gene in patients with ischemic and haemorrhagic stroke, with or without arterial hypertension.
Material and methods. DNA from peripheral blood of 87 patients with recent cerebral stroke, aged 30 to 65, was analysed. The cerebral stroke was diagnosed on the basis of focal neurological symptoms persisting for more than 24 hours, confirmed by CT or NRM imaging. The control group consisted of 45 volunteers aged 30 to 65. ACE genotype was examined using PCR.
Results. Investigation of insertion/deletion polymorphism of angiotensin-converting encoding gene gave the following results: in the ischemic stroke group: II -18.2%, ID - 60.6%, DD - 21.2%, in haemorrhagic stroke: II - 23.8%, ID - 42.9%, DD- 33.3%, in the control group: II - 24.5%, ID - 42.2%, DD - 33.3%.
Conclusions. Our results, like the conclusions of most researchers, point to absence of relationship between the type of ACE polymorphism and the prevalence of cerebral stroke. This polymorphism plays no major role in the pathogenesis of cerebral stroke.
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Keywords

cerebral stroke; angiotensin-converting enzyme; ACE; gene polymorphism

About this article
Title

Polymorphism of the angiotensin-converting enzyme encoding gene in stroke patients

Journal

Interdisciplinary Problems of Stroke

Issue

Vol 9, No 1 (2007)

Pages

8-13

Published online

2007-03-14

Bibliographic record

Udar Mózgu. Problemy Interdyscyplinarne 2007;9(1):8-13.

Keywords

cerebral stroke
angiotensin-converting enzyme
ACE
gene polymorphism

Authors

Barbara Gaweł
Andrzej Wajgt
Sabina Gałka
Joanna Głogowska-Ligus
Urszula Mazurek
Joanna Pilsch-Kowalczyk

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