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Vol 9, No 2 (2007)
Prace oryginalne
Published online: 2007-07-09
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Analysis of thrombolytic treatment for acute ischemic strokefor acute ischemic stroke based on own experiences

Konstanty Gurański, Tomasz Zięba, Leszek Kowalczyk, Ryszard Podemski
Udar Mózgu. Problemy Interdyscyplinarne 2007;9(2):47-51.

open access

Vol 9, No 2 (2007)
Prace oryginalne
Published online: 2007-07-09

Abstract


Background. Intravenous recombinant tissue plasminogen activator (rt-PA) therapy is an effective treatment for acute ischemic stroke. However, the widespread use of rt-PA in clinical practice is limited by 3-hours treatment window and the risk of hemorrhage complication. The purpose of our study was assessment the safety and efficacy rt-PA treatment at 3 neurological departments in Wroclaw.
Material and methods. The study were included 20 patients with acute ischemic stroke treated with rt-PA at 3 neurological departments in Wroclaw between 2004 and 2007. Thrombolytic therapy used according the POLKARD protocol. We assessed the rate of rt-PA treatment for ischemic stroke, time from stroke onset to treatment, severity of neurological deficit during the first 24 hours and rt-PA treatment complication.
Results. 1.4% of all patients with acute ischemic stroke were treated with rt-PA. The mean time from stroke onset to treatment was 2 hours and 28 minutes. Parenchimal hemorrhage occurred in 5% of patients. 4 patients (20%) experienced an early clinical deterioration following an initial improvement. Assessment after 1 month revealed that 15% of patient died and 65% of patients had good or moderate outcome (0-3 score in modified Rankin Scale).
Conclusions. Thrombolytic therapy outcomes and rate of hemorrhagic complications in our study were similar to randomised trials and another retrospective studies. The present study demonstrate a small number of patients that receive rt-PA, a low risk of hemorrhage complication and high rate an early clinical deterioration following an initial improvement probably associated with early arterial reocclusion.

Abstract


Background. Intravenous recombinant tissue plasminogen activator (rt-PA) therapy is an effective treatment for acute ischemic stroke. However, the widespread use of rt-PA in clinical practice is limited by 3-hours treatment window and the risk of hemorrhage complication. The purpose of our study was assessment the safety and efficacy rt-PA treatment at 3 neurological departments in Wroclaw.
Material and methods. The study were included 20 patients with acute ischemic stroke treated with rt-PA at 3 neurological departments in Wroclaw between 2004 and 2007. Thrombolytic therapy used according the POLKARD protocol. We assessed the rate of rt-PA treatment for ischemic stroke, time from stroke onset to treatment, severity of neurological deficit during the first 24 hours and rt-PA treatment complication.
Results. 1.4% of all patients with acute ischemic stroke were treated with rt-PA. The mean time from stroke onset to treatment was 2 hours and 28 minutes. Parenchimal hemorrhage occurred in 5% of patients. 4 patients (20%) experienced an early clinical deterioration following an initial improvement. Assessment after 1 month revealed that 15% of patient died and 65% of patients had good or moderate outcome (0-3 score in modified Rankin Scale).
Conclusions. Thrombolytic therapy outcomes and rate of hemorrhagic complications in our study were similar to randomised trials and another retrospective studies. The present study demonstrate a small number of patients that receive rt-PA, a low risk of hemorrhage complication and high rate an early clinical deterioration following an initial improvement probably associated with early arterial reocclusion.
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Keywords

ischemic stroke; thrombolytic therapy

About this article
Title

Analysis of thrombolytic treatment for acute ischemic strokefor acute ischemic stroke based on own experiences

Journal

Interdisciplinary Problems of Stroke

Issue

Vol 9, No 2 (2007)

Pages

47-51

Published online

2007-07-09

Bibliographic record

Udar Mózgu. Problemy Interdyscyplinarne 2007;9(2):47-51.

Keywords

ischemic stroke
thrombolytic therapy

Authors

Konstanty Gurański
Tomasz Zięba
Leszek Kowalczyk
Ryszard Podemski

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