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Vol 12, No 1-2 (2010)
Prace oryginalne
Published online: 2011-07-05
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Hiperhomocysteinemia in ischaemic stroke — clinical implications

Małgorzata Wichlińska-Lubińska, Ignacy Lubiński
Udar Mózgu. Problemy Interdyscyplinarne 2010;12(1-2):10-19.

open access

Vol 12, No 1-2 (2010)
Prace oryginalne
Published online: 2011-07-05

Abstract

Background. Ischaemic stroke represents serious health problem of contemporary society; it is one of the most frequent circulatory disturbances, the third most common cause of death and the leading cause of disability in the population over 40 years of age. The aim of the study was an assesment prevalence of high homocysteine (Hcy) concentration among ischaemic stroke patients and relationship between hyperhomocysteinemia and the course of stroke, type and number of strokes.
Material and methods. 300 patients with ischaemic stroke treated in the Department of Neurology between May 2005 and January 2006 were examined.Risk factors of stroke were assessed in anamnesis. In the first 24 hours the concentration of Hcy, cholesterol and triglyceride was measured. The patients were examined at their admission to hospital, on the last day of their hospitalization and 3 months after stroke applying the scales of Barthel and Rankin.Death rate during hospitalization and in the period of 3 months after hospitalization was analysed. Etiology of stroke was established in clasiffiaction of TOAST.
Results. High Hcy concentration was found in 47% patients with ischamic stroke. Concentration of Hcy increases with age,whereas no connection was found with sex. In statistic analyses it was found that hyperhomocysteinemia was connected with a more severe state of patients in the first 24 hours of stroke,whereas no connection was found with the patients’ state on the last day of hospitalization or 3 months after getting ill. There was no connection found between mortality during hospitalization and high Hcy concentration; positive correlation between hyperhomocysteinemia and quantity of deaths within 3 months after stroke was observed. There was no connnection found between high Hcy concentration and type of stroke or number of strokes. In logistic regression it was found positive correlation between hyperhomocysteinamia and age, diabetes and smoke.
Conclusions. 1) Prevalence of high Hcy concentration among ischaemic stroke patients was 47%. 2) Concentration of Hcy increases with age,whereas no connection was found with sex. 3) The high concentratio of Hcy results in more severe patients’ state in the first 24 hours and in an increased mortality within 3 months after stroke. 4) The high concentration of Hcy does not have any connection with the patients’ state on the last day of the hospitalization and 3 months after stroke and with mortality during hospitalization. 5) There was no connection found between hyperhomocysteinemia and type of stroke and number of strokes. 6) There was found positive correlation between hyperhomocysteinemia and others risk factors of stroke: age, diabetes and smoke.
Interdisciplinary Problems of Stroke 2010; 12 (1–2): 10–19

Abstract

Background. Ischaemic stroke represents serious health problem of contemporary society; it is one of the most frequent circulatory disturbances, the third most common cause of death and the leading cause of disability in the population over 40 years of age. The aim of the study was an assesment prevalence of high homocysteine (Hcy) concentration among ischaemic stroke patients and relationship between hyperhomocysteinemia and the course of stroke, type and number of strokes.
Material and methods. 300 patients with ischaemic stroke treated in the Department of Neurology between May 2005 and January 2006 were examined.Risk factors of stroke were assessed in anamnesis. In the first 24 hours the concentration of Hcy, cholesterol and triglyceride was measured. The patients were examined at their admission to hospital, on the last day of their hospitalization and 3 months after stroke applying the scales of Barthel and Rankin.Death rate during hospitalization and in the period of 3 months after hospitalization was analysed. Etiology of stroke was established in clasiffiaction of TOAST.
Results. High Hcy concentration was found in 47% patients with ischamic stroke. Concentration of Hcy increases with age,whereas no connection was found with sex. In statistic analyses it was found that hyperhomocysteinemia was connected with a more severe state of patients in the first 24 hours of stroke,whereas no connection was found with the patients’ state on the last day of hospitalization or 3 months after getting ill. There was no connection found between mortality during hospitalization and high Hcy concentration; positive correlation between hyperhomocysteinemia and quantity of deaths within 3 months after stroke was observed. There was no connnection found between high Hcy concentration and type of stroke or number of strokes. In logistic regression it was found positive correlation between hyperhomocysteinamia and age, diabetes and smoke.
Conclusions. 1) Prevalence of high Hcy concentration among ischaemic stroke patients was 47%. 2) Concentration of Hcy increases with age,whereas no connection was found with sex. 3) The high concentratio of Hcy results in more severe patients’ state in the first 24 hours and in an increased mortality within 3 months after stroke. 4) The high concentration of Hcy does not have any connection with the patients’ state on the last day of the hospitalization and 3 months after stroke and with mortality during hospitalization. 5) There was no connection found between hyperhomocysteinemia and type of stroke and number of strokes. 6) There was found positive correlation between hyperhomocysteinemia and others risk factors of stroke: age, diabetes and smoke.
Interdisciplinary Problems of Stroke 2010; 12 (1–2): 10–19
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Keywords

homocysteine; atherosclerosis; ischaemic stroke

About this article
Title

Hiperhomocysteinemia in ischaemic stroke — clinical implications

Journal

Interdisciplinary Problems of Stroke

Issue

Vol 12, No 1-2 (2010)

Pages

10-19

Published online

2011-07-05

Bibliographic record

Udar Mózgu. Problemy Interdyscyplinarne 2010;12(1-2):10-19.

Keywords

homocysteine
atherosclerosis
ischaemic stroke

Authors

Małgorzata Wichlińska-Lubińska
Ignacy Lubiński

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