Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Journal of Sexual and Mental Health
MENU
Shortcuts Submit an article Author Guidelines Reviewers 2022 Editorial Team

open access

Vol 18 (2020): Continuous Publishing
Review paper
Published online: 2020-10-28
View PDF (Polish) Download PDF file
Get Citation

Female sexual dysfunction in affective disorders

Aleksandra Pięta1, Anna Mosiołek1
DOI: 10.5603/SP.2020.0003
·
Seksuologia Polska 2020;18.
Affiliations
  1. Mazowieckie Specjalistyczne Centrum Zdrowia im. Prof. Jana Mazurkiewicza, Pruszków, Poland

open access

Vol 18 (2020): Continuous Publishing
Review papers
Published online: 2020-10-28

Abstract

The aim of this article is to discuss the factors influencing the occurrence of sexual dysfunctions in the course of depression and bipolar disorder in women. The authors of the study reviewed the literature available in the PubMed and Scopus databases for the period from January 1, 2010 to March 31, 2020. Research emphasizes the role of sexual dysfunction as a symptom of the disease, and also highlights the dependence on pharmacotherapy, comorbidities and sleep disorders. Understanding the type and causes of sexual dysfunctions in patients may improve compliance, and thus translate into better results of the therapy. Based on available sources, possible directions for future research can also be determined.

Abstract

The aim of this article is to discuss the factors influencing the occurrence of sexual dysfunctions in the course of depression and bipolar disorder in women. The authors of the study reviewed the literature available in the PubMed and Scopus databases for the period from January 1, 2010 to March 31, 2020. Research emphasizes the role of sexual dysfunction as a symptom of the disease, and also highlights the dependence on pharmacotherapy, comorbidities and sleep disorders. Understanding the type and causes of sexual dysfunctions in patients may improve compliance, and thus translate into better results of the therapy. Based on available sources, possible directions for future research can also be determined.

Full Text:

View PDF (Polish) Download PDF file
Get Citation

Keywords

female sexual dysfunction, affective disorders, depression, major depressive disorder, bipolar disorder, mania

About this article
Title

Female sexual dysfunction in affective disorders

Journal

Journal of Sexual and Mental Health

Issue

Vol 18 (2020): Continuous Publishing

Article type

Review paper

Published online

2020-10-28

Page views

522

Article views/downloads

53

DOI

10.5603/SP.2020.0003

Bibliographic record

Seksuologia Polska 2020;18.

Keywords

female sexual dysfunction
affective disorders
depression
major depressive disorder
bipolar disorder
mania

Authors

Aleksandra Pięta
Anna Mosiołek

References (69)
  1. World Association for Sexual Health (WAS) Declaration of sexual rights. 2014 . https://worldsexualhealth.net/wp-content/uploads/2013/08/declaration_of_sexual_rights_sep03_2014.pdf (6.02.2020).
  2. McMillan E, Adan Sanchez A, Bhaduri A, et al. Sexual functioning and experiences in young people affected by mental health disorders. Psychiatry Res. 2017; 253: 249–255.
    CrossRefPubMed
  3. Piontek A, Szeja J, Błachut M, et al. Sexual problems in the patients with psychiatric disorders. Wiad Lek. 2019; 72(10): 1984–1988.
    PubMed
  4. Ahmadzadeh G, Shahin A. Sexual dysfunctions in the patients hospitalized in psychiatric wards compared to other specialized wards in Isfahan, Iran, in 2012. Adv Biomed Res. 2015; 4: 225.
    CrossRefPubMed
  5. Clayton AH, Croft HA, Handiwala L. Antidepressants and sexual dysfunction: mechanisms and clinical implications. Postgrad Med. 2014; 126(2): 91–99.
    CrossRefPubMed
  6. Thakurta RG, Singh OmP, Bhattacharya A, et al. Nature of sexual dysfunctions in major depressive disorder and its impact on quality of life. Indian J Psychol Med. 2012; 34(4): 365–370.
    CrossRefPubMed
  7. Lai CH. Major depressive disorder: gender differences in symptoms, life quality, and sexual function. J Clin Psychopharmacol. 2011; 31(1): 39–44.
    CrossRefPubMed
  8. Sreelakshmy K, Velayudhan R, Kuriakose D, et al. Sexual dysfunction in females with depression: a cross-sectional study. Trends Psychiatry Psychother. 2017; 39(2): 106–109.
    CrossRefPubMed
  9. Namli Z, Karakuş G, Tamam L. Assessment of Dyadic Adjustment and Sexual Functions in Patients with Bipolar Disorder. Noro Psikiyatr Ars. 2018; 55(2): 171–176.
    CrossRefPubMed
  10. Lee TI, Issac J, Lin SH, et al. Gender difference in antidepressant-related sexual dysfunction in Taiwan. Gen Hosp Psychiatry. 2013; 35(4): 407–411.
    CrossRefPubMed
  11. Porto R. [Depressive symptoms and sexuality]. Presse Med. 2014; 43(10 Pt 1): 1111–1115.
    CrossRefPubMed
  12. Chokka PR, Hankey JR. Assessment and management of sexual dysfunction in the context of depression. Ther Adv Psychopharmacol. 2018; 8(1): 13–23.
    CrossRefPubMed
  13. Lorenz T, Rullo J, Faubion S. Antidepressant-Induced Female Sexual Dysfunction. Mayo Clin Proc. 2016; 91(9): 1280–1286.
    CrossRefPubMed
  14. Atlantis E, Sullivan T. Bidirectional association between depression and sexual dysfunction: a systematic review and meta-analysis. J Sex Med. 2012; 9(6): 1497–1507.
    CrossRefPubMed
  15. Lin CF, Juang YY, Wen JK, et al. Correlations between sexual dysfunction, depression, anxiety, and somatic symptoms among patients with major depressive disorder. Chang Gung Med J. 2012; 35(4): 323–331.
    CrossRefPubMed
  16. Forbes MK, Baillie AJ, Eaton NR, et al. A Place for Sexual Dysfunctions in an Empirical Taxonomy of Psychopathology. J Sex Res. 2017; 54(4-5): 465–485.
    CrossRefPubMed
  17. Nascimento ER, Maia ACO, Nardi AE, et al. Sexual dysfunction in arterial hypertension women: The role of depression and anxiety. J Affect Disord. 2015; 181: 96–100.
    CrossRefPubMed
  18. Bak E, Marcisz C, Krzeminska S, et al. Does Type 1 Diabetes Modify Sexuality and Mood of Women and Men? Int J Environ Res Public Health. 2018; 15(5).
    CrossRefPubMed
  19. Krysiak R, Kowalcze K, Okopień B. Sexual function and depressive symptoms in young women with overt hyperthyroidism. Eur J Obstet Gynecol Reprod Biol. 2019; 234: 43–48.
    CrossRefPubMed
  20. Prairie BA, Wisniewski SR, Luther J, et al. Symptoms of depressed mood, disturbed sleep, and sexual problems in midlife women: cross-sectional data from the Study of Women's Health Across the Nation. J Womens Health (Larchmt). 2015; 24(2): 119–126.
    CrossRefPubMed
  21. Reddy RM, Saravanan RA, Praharaj SK, et al. Sexual Dysfunction in Women with Depression: A Hospital-Based Cross-sectional Comparative Study. Indian J Psychol Med. 2020; 42(1): 46–51.
    CrossRefPubMed
  22. Ishak WW, Christensen S, Sayer G, et al. Sexual satisfaction and quality of life in major depressive disorder before and after treatment with citalopram in the STAR*D study. J Clin Psychiatry. 2013; 74(3): 256–261.
    CrossRefPubMed
  23. Kalmbach DA, Kingsberg SA, Ciesla JA. How changes in depression and anxiety symptoms correspond to variations in female sexual response in a nonclinical sample of young women: a daily diary study. J Sex Med. 2014; 11(12): 2915–2927.
    CrossRefPubMed
  24. Kopeykina I, Kim HJ, Khatun T, et al. Hypersexuality and couple relationships in bipolar disorder: A review. J Affect Disord. 2016; 195: 1–14.
    CrossRefPubMed
  25. Sørensen T, Giraldi A, Vinberg M. Sexual distress and quality of life among women with bipolar disorder. Int J Bipolar Disord. 2017; 5(1): 29.
    CrossRefPubMed
  26. Grover S, Nehra R, Thakur A. Bipolar affective disorder and its impact on various aspects of marital relationship. Ind Psychiatry J. 2017; 26(2): 114–120.
    CrossRefPubMed
  27. Rowe LS, Morris AM. Patient and partner correlates of couple relationship functioning in bipolar disorder. J Fam Psychol. 2012; 26(3): 328–337.
    CrossRefPubMed
  28. Morehouse R, Macqueen G, Kennedy SH. Barriers to achieving treatment goals: a focus on sleep disturbance and sexual dysfunction. J Affect Disord. 2011; 132 Suppl 1: S14–S20.
    CrossRefPubMed
  29. Clayton AH, Croft HA, Handiwala L. Antidepressants and sexual dysfunction: mechanisms and clinical implications. Postgrad Med. 2014; 126(2): 91–99.
    CrossRefPubMed
  30. Montejo AL, Montejo L, Baldwin DS. The impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management. World Psychiatry. 2018; 17(1): 3–11.
    CrossRefPubMed
  31. Olisah VO, Sheikh TL, Abah ER, et al. Sociodemographic and clinical correlates of sexual dysfunction among psychiatric outpatients receiving common psychotropic medications in a Neuropsychiatric Hospital in Northern Nigeria. Niger J Clin Pract. 2016; 19(6): 799–806.
    CrossRefPubMed
  32. Gelenberg AJ, Dunner DL, Rothschild AJ, et al. Sexual functioning in patients with recurrent major depressive disorder enrolled in the PREVENT study. J Nerv Ment Dis. 2013; 201(4): 266–273.
    CrossRefPubMed
  33. Hatta S, Duni A, Ng CG, et al. Effects of Selective Serotonin Reuptake Inhibitors (SSRIs) therapy on the female sexual response cycle of women with major depression. Clin Ter. 2013; 164(1): 11–15.
    CrossRefPubMed
  34. La Torre A, Giupponi G, Duffy D, et al. Sexual dysfunction related to psychotropic drugs: a critical review--part I: antidepressants. Pharmacopsychiatry. 2013; 46(5): 191–199.
    CrossRefPubMed
  35. Baldwin DS, Manson C, Nowak M. Impact of Antidepressant Drugs on Sexual Function and Satisfaction. CNS Drugs. 2015; 29(11): 905–913.
    CrossRefPubMed
  36. Midi M, Kanagasundram S, Sidi H, et al. Sexual arousal difficulties in women treated with antidepressants: a comparison between escitalopram and fluoxetine. Int J Psychiatry Med. 2012; 43(4): 405–418.
    CrossRefPubMed
  37. Lorenz T, Rullo J, Faubion S. Antidepressant-Induced Female Sexual Dysfunction. Mayo Clin Proc. 2016; 91(9): 1280–1286.
    CrossRefPubMed
  38. Khazaie H, Rezaie L, Rezaei Payam N, et al. Antidepressant-induced sexual dysfunction during treatment with fluoxetine, sertraline and trazodone; a randomized controlled trial. Gen Hosp Psychiatry. 2015; 37(1): 40–45.
    CrossRefPubMed
  39. Sapetti A. Agomelatine: an antidepressant without deterioration of sexual response. J Sex Marital Ther. 2012; 38(2): 190–197.
    CrossRefPubMed
  40. Montejo AL, Montejo L, Baldwin DS. The impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management. World Psychiatry. 2018; 17(1): 3–11.
    CrossRefPubMed
  41. Clayton AH, Tsai J, Mao Y, et al. Effect of Lurasidone on Sexual Function in Major Depressive Disorder Patients With Subthreshold Hypomanic Symptoms (Mixed Features): Results From a Placebo-Controlled Trial. J Clin Psychiatry. 2018; 79(5).
    CrossRefPubMed
  42. Preeti S, Jayaram SD, Chittaranjan A. Sexual Dysfunction in Patients with Antidepressant-treated Anxiety or Depressive Disorders: a Pragmatic Multivariable Longitudinal Study. East Asian Arch Psychiatry. 2018; 28(1): 9–16.
    PubMed
  43. Reisman Y. Post-SSRI sexual dysfunction. BMJ. 2020: m754.
    CrossRef
  44. Grover S, Ghosh A, Sarkar S, et al. Sexual dysfunction in clinically stable patients with bipolar disorder receiving lithium. J Clin Psychopharmacol. 2014; 34(4): 475–482.
    CrossRefPubMed
  45. Elnazer HY, Sampson A, Baldwin D. Lithium and sexual dysfunction: an under-researched area. Hum Psychopharmacol. 2015; 30(2): 66–69.
    CrossRefPubMed
  46. García-Blanco A, García-Portilla MP, Fuente-Tomás Ld, et al. Sexual Dysfunction and Mood Stabilizers in Long-Term Stable Patients With Bipolar Disorder. J Sex Med. 2020; 17(5): 930–940.
    CrossRefPubMed
  47. Grover S, Nehra R, Thakur A. Bipolar affective disorder and its impact on various aspects of marital relationship. Ind Psychiatry J. 2017; 26(2): 114–120.
    CrossRefPubMed
  48. Krysiak R, Drosdzol-Cop A, Skrzypulec-Plinta V, et al. Sexual Function and Depressive Symptoms in Young Women With Nonclassic Congenital Adrenal Hyperplasia. J Sex Med. 2016; 13(1): 34–39.
    CrossRefPubMed
  49. Kumsar Ş, Kumsar NA, Sağlam HS, et al. Testosterone levels and sexual function disorders in depressive female patients: effects of antidepressant treatment. J Sex Med. 2014; 11(2): 529–535.
    CrossRefPubMed
  50. Krysiak R, Kowalcze K, Okopień B. Sexual function and depressive symptoms in young women with overt hyperthyroidism. Eur J Obstet Gynecol Reprod Biol. 2019; 234: 43–48.
    CrossRefPubMed
  51. Krysiak R, Drosdzol-Cop A, Skrzypulec-Plinta V, et al. Sexual function and depressive symptoms in young women with thyroid autoimmunity and subclinical hypothyroidism. Clin Endocrinol (Oxf). 2016; 84(6): 925–931.
    CrossRefPubMed
  52. Atis G, Dalkilinc A, Altuntas Y, et al. Hyperthyroidism: a risk factor for female sexual dysfunction. J Sex Med. 2011; 8(8): 2327–2333.
    CrossRefPubMed
  53. Atis G, Dalkilinc A, Altuntas Y, et al. Sexual dysfunction in women with clinical hypothyroidism and subclinical hypothyroidism. J Sex Med. 2010; 7(7): 2583–2590.
    CrossRefPubMed
  54. Krysiak R, Szkróbka W, Okopień B. The effect of bromocriptine treatment on sexual functioning and depressive symptoms in women with mild hyperprolactinemia. Pharmacol Rep. 2018; 70(2): 227–232.
    CrossRefPubMed
  55. Rubio-Abadal E, Del Cacho N, Saenz-Navarrete G, et al. PROLACT Group. How Hyperprolactinemia Affects Sexual Function in Patients Under Antipsychotic Treatment. J Clin Psychopharmacol. 2016; 36(5): 422–428.
    CrossRefPubMed
  56. Celik O, Hatipoglu E, Akhan SE, et al. Acromegaly is associated with higher frequency of female sexual dysfunction: experience of a single center. Endocr J. 2013; 60(6): 753–761.
    CrossRefPubMed
  57. Krysiak R, Drosdzol-Cop A, Skrzypulec-Plinta V, et al. Sexual Functioning and Depressive Symptoms in Women with Diabetes and Prediabetes Receiving Metformin Therapy: A Pilot Study. Exp Clin Endocrinol Diabetes. 2017; 125(1): 42–48.
    CrossRefPubMed
  58. Tagliabue M, Gottero C, Zuffranieri M, et al. Sexual function in women with type 1 diabetes matched with a control group: depressive and psychosocial aspects. J Sex Med. 2011; 8(6): 1694–1700.
    CrossRefPubMed
  59. Oyekçin DG, Gülpek D, Sahin EM, et al. Depression, anxiety, body image, sexual functioning, and dyadic adjustment associated with dialysis type in chronic renal failure. Int J Psychiatry Med. 2012; 43(3): 227–241.
    CrossRefPubMed
  60. Alariny AF, Farid CI, Elweshahi HM, et al. Psychological and Sexual Consequences of Psoriasis Vulgaris on Patients and Their Partners. J Sex Med. 2019; 16(12): 1900–1911.
    CrossRefPubMed
  61. Ferreira BR, Pio-Abreu JL, Reis JP, et al. Analysis of the Prevalence of Mental Disorders in Psoriasis: The Relevance of Psychiatric Assessment in Dermatology. Psychiatr Danub. 2017; 29(4): 401–406.
    CrossRefPubMed
  62. Rathore C, Henning OJ, Luef G, et al. Sexual dysfunction in people with epilepsy. Epilepsy Behav. 2019; 100(Pt A): 106495.
    CrossRefPubMed
  63. Zelená V, Kuba R, Soška V, et al. Depression as a prominent cause of sexual dysfunction in women with epilepsy. Epilepsy Behav. 2011; 20(3): 539–544.
    CrossRefPubMed
  64. Silveira C, Guedes R, Maia D, et al. Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art. Psychiatry Investig. 2019; 16(12): 877–888.
    CrossRefPubMed
  65. Varanda S, Ribeiro da Silva J, Costa AS, et al. Sexual dysfunction in women with Parkinson's disease. Mov Disord. 2016; 31(11): 1685–1693.
    CrossRefPubMed
  66. Seehuus M, Pigeon W. The sleep and sex survey: Relationships between sexual function and sleep. J Psychosom Res. 2018; 112: 59–65.
    CrossRefPubMed
  67. Afsahri P, Salehnejad Z, Hekmat K, et al. Do Sleeping Disorders Impair Sexual Function in Married Iranian Women of Reproductive Age? Results from a Cross-Sectional Study. Psychiatry J. 2018; 2018: 1045738.
    CrossRefPubMed
  68. Prairie BA, Wisniewski SR, Luther J, et al. Symptoms of depressed mood, disturbed sleep, and sexual problems in midlife women: cross-sectional data from the Study of Women's Health Across the Nation. J Womens Health (Larchmt). 2015; 24(2): 119–126.
    CrossRefPubMed
  69. Reynaert C, Zdanowicz N, Janne P, et al. Jacques D. Depression and sexuality Psychiatr Danub 2010 Nov;22 :S111-3 PMID. ; 21057415(Suppl 1).

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Wydawcą serwisu jest VM Media Group sp. z o.o., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl