Vol 27, No 2 (2022)
Review paper
Published online: 2022-02-08

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Integrating stereotactic radiotherapy and systemic therapies

Isabella Palumbo1, Francesco Pasqualetti2, Durim Delishaj2, Alessandra Gonnelli2, Cynthia Aristei1, Simona Borghesi3, Luigi Pirtoli4, Liliana Belgioia5, Stefano Arcangeli6
Rep Pract Oncol Radiother 2022;27(2):310-317.


This paper focuses on stereotactic radiotherapy (SRT) interactions with targeted therapies and immune system modulating agents because SRT inevitably interacts with them in the treatment of oligometastatic patients.

Radiation oncologists need to be aware of the advantages and risks of these interactions which can, on one hand, enhance the effect of therapy or, on the other, potentiate reciprocal toxicities. To date, few prospective studies have evaluated the interactions of SRT with new-generation drugs and data are mainly based on retrospective experiences, which are often related to small sample sizes.

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