Vol 27, No 1 (2022)
Technical note
Published online: 2022-01-24

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Intraoperative near-infrared molecular imaging for diagnostic thoracoscopy in difficult clinical scenario

Francesco Guerrera12, Federico Femia23, Paraskevas Lyberis2, Pier Luigi Filosso12, Paolo Olivo Lausi21, Enrico Ruffini21
Rep Pract Oncol Radiother 2022;27(1):176-179.


Precise diagnosis in intrathoracic malignancies is paramount for adequate treatment planning. Standard approach is histologic analysis from targeted biopsy obtained with different invasive procedures. Rarely, in difficult clinical scenarios, even gold standard diagnostic procedures can be ineffective in obtaining a satisfying result. Procedural developments and technological improvements applied to the chosen technique can be helpful to deal with such situation. We present two clinical cases of suspected intrathoracic malignancy in which repeated unsuccessful diagnostic procedures had already been attempted. We adopted a protocol based on intraoperative fluorescence during diagnostic thoracoscopy to increase diagnostic efficacy. In both cases we obtained a precise pathological diagnosis.

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Reports of Practical Oncology and Radiotherapy