Vol 26, No 3 (2021)
Letter to the Editor
Published online: 2021-03-26

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Could patients benefit from whole-brain radiotherapy with unilateral hippocampus sparing?

Lucas Gomes Sapienza1, Michelle S. Ludwig1, Jacob J. Mandel2, Dung H. Nguyen1, Alfredo Enrique Echeverria1
Rep Pract Oncol Radiother 2021;26(3):454-456.


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  1. Scoville WB, Milner B. Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry. 1957; 20(1): 11–21.
  2. Di Gennaro G, Grammaldo LG, Quarato PP, et al. Severe amnesia following bilateral medial temporal lobe damage occurring on two distinct occasions. Neurol Sci. 2006; 27(2): 129–133.
  3. Zola-Morgan S, Squire LR, Amaral DG. Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci. 1986; 6(10): 2950–2967.
  4. Brown PD, Gondi V, Pugh S, et al. for NRG Oncology. Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001. J Clin Oncol. 2020; 38(10): 1019–1029.
  5. Pospisil P, Kazda T, Hynkova L, et al. Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study. Radiother Oncol. 2017; 122(3): 373–379.
  6. Goda JS, Dutta D, Krishna U, et al. Hippocampal radiotherapy dose constraints for predicting long-term neurocognitive outcomes: mature data from a prospective trial in young patients with brain tumors. Neuro Oncol. 2020; 22(11): 1677–1685.
  7. Fiorentino A, Tebano U, Sicignano G, et al. Hippocampal dose during Linac-based stereotactic radiotherapy for brain metastases: An observational study. Phys Med. 2018; 49: 135–138.
  8. Giaj Levra N, Sicignano G, Fiorentino A, et al. Whole brain radiotherapy with hippocampal avoidance and simultaneous integrated boost for brain metastases: a dosimetric volumetric-modulated arc therapy study. Radiol Med. 2016; 121(1): 60–69.
  9. Kazda T, Vrzal M, Prochazka T, et al. Left hippocampus sparing whole brain radiotherapy (WBRT): A planning study. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017; 161(4): 397–402.

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